K
K.-M. Alexacou
Researcher at China Pharmaceutical University
Publications - 9
Citations - 521
K.-M. Alexacou is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Glycogen phosphorylase & Ligand (biochemistry). The author has an hindex of 8, co-authored 9 publications receiving 495 citations.
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Journal ArticleDOI
Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies†
Xiaoan Wen,Hongbin Sun,Jun Liu,Keguang Cheng,Pu Zhang,Liying Zhang,Jia Hao,Luyong Zhang,Peizhou Ni,Spyros E. Zographos,Demetres D. Leonidas,K.-M. Alexacou,Thanasis Gimisis,Joseph Hayes,Nikos G. Oikonomakos +14 more
TL;DR: Pentacyclic triterpenes represent a promising class of multiple-target antidiabetic agents that exert hypoglycemic effects, at least in part, through GP inhibition.
Journal ArticleDOI
New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents
László Somsák,Katalin Czifrák,Marietta Tóth,Éva Bokor,Evangelia D. Chrysina,K.-M. Alexacou,Joseph Hayes,C. Tiraidis,E. Lazoura,Demetres D. Leonidas,Spyros E. Zographos,Nikos G. Oikonomakos +11 more
TL;DR: The synthesis, structure determination and computational studies of the most recent inhibitors of glycogen phosphorylase at the different binding sites are presented and analyzed and have the potential to facilitate structure-based drug design.
Journal ArticleDOI
Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case
Evangelia D. Chrysina,Éva Bokor,K.-M. Alexacou,Maria Despoina Charavgi,George N. Oikonomakos,Spyros E. Zographos,Demetres D. Leonidas,Nikos G. Oikonomakos,László Somsák +8 more
TL;DR: In this paper, the same azide and substituted acetylenes gave 1-(β-d -glucopyranosyl)-4-substituted-1,2,3-triazoles in Cu(I)-catalyzed azide-alkyne cycloadditions.
Journal ArticleDOI
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Mahmoud Benltifa,Joseph Hayes,Sébastien Vidal,David Gueyrard,Peter G. Goekjian,Jean-Pierre Praly,Gregory Kizilis,C. Tiraidis,K.-M. Alexacou,Evangelia D. Chrysina,Spyros E. Zographos,Demetres D. Leonidas,Georgios Archontis,Nikos G. Oikonomakos +13 more
TL;DR: Docking calculations with GLIDE in extra-precision (XP) mode yielded excellent agreement with experiment, as judged by comparison of the predicted binding modes of the five ligands with the crystallographic conformations and the good correlation between the docking scores and the experimental free binding energies.
Journal ArticleDOI
Crystallographic and computational studies on 4‐phenyl‐N‐(β‐D‐glucopyranosyl)‐1H‐1,2,3‐triazole‐1‐acetamide, an inhibitor of glycogen phosphorylase: Comparison with α‐D‐glucose, N‐acetyl‐β‐D‐glucopyranosylamine and N‐benzoyl‐N′‐β‐D‐glucopyranosyl urea binding
K.-M. Alexacou,Joseph Hayes,C. Tiraidis,Spyros E. Zographos,Demetres D. Leonidas,Evangelia D. Chrysina,Georgios Archontis,Nikos G. Oikonomakos,Jashuva V. Paul,Babu Varghese,Duraikkannu Loganathan +10 more
TL;DR: In this article, the structure of GPb in complex with glucosyltriazolylacetamide at 100 K to 188 A resolution was determined, with and without the crystallographic ordered cavity waters using the GoldScore scoring function.