Kai Wang

TL;DR: Findings indicate that RAGE/ligand interaction plays a key role in neointimal formation after vascular injury irrespective of diabetes status and suggest a novel target to minimize neointedimal hyperplasia.

TL;DR: Increased expression of TSP-1 in blood vessels in diabetes may represent a new link between diabetes, atherogenesis, and accelerated restenosis, and may be a direct response of vascular cells to glucose.

TL;DR: It is demonstrated for the first time that PPARγ agonists inhibit RAGE expression at sites of arterial injury and suggest that down-regulation of RAGE by the PParγ activation inhibits neointimal formation in response to arterial Injury.

TL;DR: Ticagrelor blocks ADP-induced platelet activation and aggregation; prevents platelet-mediated thrombosis; prolongs reperfusion time and reduces re-occlusion and cyclic flow variation; and significantly decreases infarct size and rapidly restores myocardial tissue perfusion.

TL;DR: The adjunctive administration of AR-C69931MX blocked ADP-mediated platelet aggregation and recruitment and prevented platelet-mediated thrombosis, resulting in prolongation of reperfusion time and a decrease in reocclusion and cyclic flow variations.