O
Olga I. Stenina
Researcher at Cleveland Clinic
Publications - 26
Citations - 1499
Olga I. Stenina is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Thrombospondin & Angiogenesis. The author has an hindex of 19, co-authored 26 publications receiving 1410 citations. Previous affiliations of Olga I. Stenina include Case Western Reserve University & Northeast Ohio Medical University.
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Journal ArticleDOI
Single Nucleotide Polymorphisms in Multiple Novel Thrombospondin Genes May Be Associated With Familial Premature Myocardial Infarction
Eric J. Topol,Jeanette J. McCarthy,Stacey Gabriel,David J. Moliterno,William J. Rogers,L. Kristin Newby,Matthew L. Freedman,Jennifer Metivier,Ruth Cannata,Christopher J. O'Donnell,Kandice Kottke-Marchant,Gurunathan Murugesan,Edward F. Plow,Olga I. Stenina,George Q. Daley +14 more
TL;DR: This large-scale genetic study has identified the potential of multiple novel variants in the thrombospondin gene family to be associated with familial premature myocardial infarction and deserves further study in familial ischemic heart disease.
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Increased Expression of Thrombospondin-1 in Vessel Wall of Diabetic Zucker Rat
Olga I. Stenina,Irene Krukovets,Kai Wang,Zhongmin Zhou,Farhad Forudi,Marc S. Penn,Eric J. Topol,Edward F. Plow +7 more
TL;DR: Increased expression of TSP-1 in blood vessels in diabetes may represent a new link between diabetes, atherogenesis, and accelerated restenosis, and may be a direct response of vascular cells to glucose.
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Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload
Ella G. Frolova,Nikolai A. Sopko,Lauren Blech,Zoran B. Popović,Jianbo Li,Amit Vasanji,Carla Drumm,Irene Krukovets,Mukesh K. Jain,Marc S. Penn,Edward F. Plow,Olga I. Stenina +11 more
TL;DR: Thrombospondin‐4 is involved in regulating the adaptive responses of the heart to pressure overload, suggesting its important role in myocardial remodeling.
Journal ArticleDOI
Thrombospondin-4 and Its Variants Expression and Differential Effects on Endothelial Cells
Olga I. Stenina,Shailesh Y. Desai,Irene Krukovets,Kelly Kight,Damir Janigro,Eric J. Topol,Edward F. Plow +6 more
TL;DR: TSP-4 is expressed by vascular cells and influences the vessel wall by modulating the proliferation of ECs and smooth muscle cells, and the A387P substitution is a “gain-of-function” mutation that may be proatherogenic.
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Thrombospondin-4 Regulates Vascular Inflammation and Atherogenesis
Ella G. Frolova,Elzbieta Pluskota,Irene Krukovets,Tim Burke,Carla Drumm,Jonathan D. Smith,Lauren Blech,Maria Febbraio,Paul Bornstein,Edward F. Plow,Olga I. Stenina +10 more
TL;DR: TSP-4 is abundant in atherosclerotic lesions and in areas prone to development of lesions and may influence the recruitment of macrophage by activating endothelial cells and directly interacting with macrophages to increase their adhesion and migration.