Z
Zhaoming Su
Researcher at Stanford University
Publications - 38
Citations - 1506
Zhaoming Su is an academic researcher from Stanford University. The author has contributed to research in topics: Acinetobacter baumannii & Biofilm. The author has an hindex of 18, co-authored 33 publications receiving 1038 citations. Previous affiliations of Zhaoming Su include Scripps Research Institute & Baylor College of Medicine.
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Journal ArticleDOI
Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS
Zhaoming Su,Yong Jie Zhang,Tania F. Gendron,Peter O. Bauer,Jeannie Chew,Wang Yong Yang,Erik Fostvedt,Karen Jansen-West,Veronique V. Belzil,Pamela Desaro,Amelia Johnston,Karen Overstreet,Seok Yoon Oh,Peter K. Todd,James D. Berry,Merit Cudkowicz,Bradley F. Boeve,Dennis W. Dickson,Mary Kay Floeter,Bryan J. Traynor,Claudia Morelli,Antonia Ratti,Vincenzo Silani,Rosa Rademakers,Robert H. Brown,Jeffrey D. Rothstein,Kevin B. Boylan,Leonard Petrucelli,Matthew D. Disney +28 more
TL;DR: It is suggested that c9RAN proteins could potentially serve as a pharmacodynamic biomarker to assess efficacy of therapies that target r(GGGGCC)exp and poly(GP) c9 RAN proteins are specifically detected in c9ALS patient cerebrospinal fluid.
Journal ArticleDOI
Measurement of atom resolvability in cryo-EM maps with Q -scores
Grigore D. Pintilie,Kaiming Zhang,Zhaoming Su,Shanshan Li,Michael F. Schmid,Wah Chiu,Wah Chiu +6 more
TL;DR: Q -score analysis of multiple cryo-EM maps of the same proteins derived from different laboratories confirms the reproducibility of structural features from side chains down to water and ion atoms, and can be used at the atom, residue or macromolecule scale.
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An intrinsically disordered peptide from ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions
Daisy W. Leung,Dominika Borek,Priya Luthra,Jennifer M. Binning,Manu Anantpadma,Gai Liu,Ian B. Harvey,Zhaoming Su,Ariel C. Endlich-Frazier,Juanli Pan,Reed S. Shabman,Wah Chiu,Robert A. Davey,Zbyszek Otwinowski,Christopher F. Basler,Gaya K. Amarasinghe +15 more
TL;DR: The structure of the NPBP/ΔNPNTD complex, solved to 3.7 Å resolution, reveals how NPBP peptide occludes a large surface area that is important for NP-NP and NP-RNA interactions and for viral RNA synthesis.
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Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures
Kalli Kappel,Kaiming Zhang,Zhaoming Su,Zhaoming Su,Andrew M. Watkins,Wipapat Kladwang,Shanshan Li,Grigore D. Pintilie,Ved V Topkar,Ramya Rangan,Ivan N Zheludev,Joseph D. Yesselman,Joseph D. Yesselman,Wah Chiu,Wah Chiu,Rhiju Das +15 more
TL;DR: It is demonstrated that cryo-electron microscopy can routinely resolve maps of RNA-only systems and that these maps enable subnanometer-resolution coordinate estimation when complemented with multidimensional chemical mapping and Rosetta DRRAFTER computational modeling.
Journal ArticleDOI
Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution.
Kaiming Zhang,Shanshan Li,Kalli Kappel,Grigore D. Pintilie,Zhaoming Su,Tung-Chung Mou,Michael F. Schmid,Rhiju Das,Wah Chiu,Wah Chiu +9 more
TL;DR: It is shown that RNA structures can be solved by cryo-EM and present the structures of a 40 kDa SAM-IV riboswitch in the apo form and bound to its ligand S-adenosylmethionine.