Showing papers by "Kamejiro Yamashita published in 1993"
TL;DR: It is demonstrated that PKC activity and related membrane lipid metabolism are altered in spastic basilar arteries after subarachnoid hemorrhage.
Abstract: Changes in protein kinase C (PKC) activity, membrane lipid metabolism, and the extent of 20-kDa myosin light chain (MLC) phosphorylation in spastic cerebral basilar arteries were examined by using ...
52 citations
TL;DR: Rat pancreas perfusion was performed to study the effects of pituitary adenylate cyclase activating polypeptide (PACAP) on pancreatic hormone release and PACAP's stimulatory effects on insulin and glucagon release were completely abolished by an equimolar and ten times lower concentration of somatostatin.
Abstract: Rat pancreas perfusion was performed to study the effects of pituitary adenylate cyclase activating polypeptide (PACAP) on pancreatic hormone release. Under the perfusate glucose concentration of 5.5 mmol/l, 0.1 nmol/l PACAP27 significantly stimulated both insulin and glucagon release. The degree of stimulation was in a dose dependent manner. The stimulation of insulin release was clearly dependent on the perfusate glucose concentration, when compared with 2.8, 5.5 and 8.3 mmol/l. The potency of PACAP38 on the stimulation of insulin release was greater than that of PACAP27 at 5.5 mmol/l of perfusate glucose concentration, but not at 8.3 mmol/l. No differences for glucagon and cAMP release were found between the two peptides. PACAP's stimulatory effects on insulin and glucagon release were completely abolished by an equimolar and ten times lower concentration of somatostatin, respectively. The physiologic significance of these potent effects of PACAP's islet hormones release must be clarified by further studies.
47 citations
TL;DR: It is shown that the increased elastin glycation in the aorta even at the early stage of diabetes is associated with calcium deposit in theAorta, which is consistent with the interpretation that elast in theaorta is the potential accelerating factor for diabetic macroangiopathy.
34 citations
TL;DR: The present study suggests that the microembolism model in freely moving rats is useful for investigations of the early phase and late phase of cerebral ischemia.
13 citations
TL;DR: In this article, the relative molecular mass (M(r)) of a native oligomeric protein and the number and M(r) of its subunits were determined simultaneously using two-dimensional electrophoresis.
9 citations