K
Karan Kapoor
Researcher at University of Illinois at Urbana–Champaign
Publications - 54
Citations - 651
Karan Kapoor is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Medicine & Lipid bilayer. The author has an hindex of 11, co-authored 46 publications receiving 385 citations. Previous affiliations of Karan Kapoor include University of Maryland Medical Center & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells.
Min Pi,Karan Kapoor,Ruisong Ye,Satoru K. Nishimoto,Jeremy C. Smith,Jeremy C. Smith,Jerome Baudry,Leigh Darryl Quarles +7 more
TL;DR: It is found that Ocn and an Ocn-derived C-terminal hexapeptide directly activate GPRC6A-dependent ERK signaling in vitro and a role for GPRc6A in regulating β-cell proliferation and insulin secretion is confirmed.
Journal ArticleDOI
Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues
Min Pi,Karan Kapoor,Yunpeng Wu,Ruisong Ye,Susan E. Senogles,Satoru K. Nishimoto,Dong Jin Hwang,Duane D. Miller,Ramesh Narayanan,Jeremy C. Smith,Jeremy C. Smith,Jerome Baudry,Jerome Baudry,L. Darryl Quarles +13 more
TL;DR: GPRC6A directly mediates the rapid signaling response to T and uncovers previously unrecognized endocrine networks, including T stimulation of insulin secretion in pancreatic islets and enzyme expression involved in the biosynthesis of T in Leydig cells.
Journal ArticleDOI
Ensemble-based docking: From hit discovery to metabolism and toxicity predictions.
Wilfredo Evangelista,Wilfredo Evangelista,Rebecca L. Weir,Rebecca L. Weir,Sally R. Ellingson,Sally R. Ellingson,Sally R. Ellingson,Jason B. Harris,Jason B. Harris,Karan Kapoor,Karan Kapoor,Jeremy C. Smith,Jeremy C. Smith,Jerome Baudry,Jerome Baudry +14 more
TL;DR: It is illustrated how ensemble-based docking can be extended beyond hit discovery and toward providing a structural basis for the prediction of metabolism and off-target binding relevant to pre-clinical and clinical trials.
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A Collaborative Cardiologist-Intensivist Management Model Improves Cardiac Intensive Care Unit Outcomes.
Karan Kapoor,Avelino C. Verceles,Giora Netzer,Amal Chaudhry,Mary Bolgiano,Sandeep Devabhakthuni,Jonathan Ludmir,Jeremy S. Pollock,Gautam V. Ramani,Michael T. McCurdy +9 more
TL;DR: Although the presence of a cardiac intensivist has been shown to reduce cardiac intensive care unit (CICU) mortality, and data from medical and surgical critical care research support multidisciplinary staffing models, the impact of collaboration between cardiologists and
Journal ArticleDOI
Novel Therapeutic Targets for Managing Dyslipidemia.
Vasanth Sathiyakumar,Karan Kapoor,Steven R. Jones,Maciej Banach,Seth S. Martin,Seth S. Martin,Peter P. Toth +6 more
TL;DR: Novel therapeutic targets regulating lipid and lipoprotein metabolism, such as apoprotein C3, angiopoietin-like proteins 3 and 4, and Lipoprotein(a), have been identified and may provide additional avenues to prevent and treat atherosclerotic disease.