K
Karen L. Christman
Researcher at University of California, San Diego
Publications - 148
Citations - 10207
Karen L. Christman is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Decellularization & Self-healing hydrogels. The author has an hindex of 51, co-authored 136 publications receiving 8680 citations. Previous affiliations of Karen L. Christman include California NanoSystems Institute & Government of the United States of America.
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Journal ArticleDOI
Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium.
Karen L. Christman,Andrew J. Vardanian,Qizhi Fang,Richard E. Sievers,Hubert H. Fok,Randall J. Lee +5 more
TL;DR: This study indicates that fibrin glue increases cell transplant survival, decreases infarct size, and increases blood flow to ischemic myocardium, suggesting fibr in glue may have potential as a biomaterial scaffold to improve cellular cardiomyoplasty treat and MIs.
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Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering
Jennifer Singelyn,Jessica A. DeQuach,Sonya B. Seif-Naraghi,Robert B. Littlefield,Pamela J. Schup-Magoffin,Karen L. Christman +5 more
TL;DR: The initial feasibility and potential of a naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering is demonstrated.
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Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction.
TL;DR: Fibrin glue is capable of preserving infarct wall thickness and cardiac function after a myocardial infarction in rats and may be useful as a biomaterial scaffold for myocardIAL cell transplantation.
Journal ArticleDOI
Biomaterials for the Treatment of Myocardial Infarction
TL;DR: An overview of the current progress in the growing field of biomaterials for the treatment of myocardial infarction is given.
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Safety and Efficacy of an Injectable Extracellular Matrix Hydrogel for Treating Myocardial Infarction
Sonya B. Seif-Naraghi,Jennifer Singelyn,Michael A. Salvatore,Kent G. Osborn,Jean J. Wang,Unatti Sampat,Oi Ling Kwan,G. Monet Strachan,Jonathan Wong,Pamela J. Schup-Magoffin,Rebecca L. Braden,Kendra Bartels,Jessica A. DeQuach,Mark C. Preul,Adam Kinsey,Anthony N. DeMaria,Nabil Dib,Karen L. Christman +17 more
TL;DR: Data in a large animal show that the myocardial ECM–derived material not only improves functional outcome after a heart attack but also is safe and nontoxic, thus making the material ready to move forward toward clinical tests in people.