K
Karen M. Hauda
Researcher at Johns Hopkins University
Publications - 7
Citations - 893
Karen M. Hauda is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Immune system & Immunotherapy. The author has an hindex of 7, co-authored 7 publications receiving 887 citations. Previous affiliations of Karen M. Hauda include Massachusetts Institute of Technology & Johns Hopkins University School of Medicine.
Papers
More filters
Journal Article
Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by ex Vivo Granulocyte-Macrophage Colony-stimulating Factor Gene Transfer
Jonathan W. Simons,Elizabeth M. Jaffee,Christine E. Weber,Hyam I. Levitsky,William G. Nelson,Michael A. Carducci,Audrey J. Lazenby,Lawrence K. Cohen,Christy C. Finn,Shirley M. Clift,Karen M. Hauda,Lisa A. Beck,Kristin M. Leiferman,Albert H. Owens,Steven Piantadosi,Glenn Dranoff,Richard C. Mulligan,Drew M. Pardoll,Fray F. Marshall +18 more
TL;DR: This Phase I study demonstrated the feasibility, safety, and bioactivity of an autologous GM-CSF gene-transduced tumor vaccine for RCC patients.
Journal Article
High Efficiency Gene Transfer into Primary Human Tumor Explants without Cell Selection
Elizabeth M. Jaffee,Glenn Dranoff,Glenn Dranoff,Lawrence K. Cohen,Karen M. Hauda,Karen M. Hauda,Shirley Clift,Fray F. Marshall,Richard C. Mulligan,Drew M. Pardoll +9 more
TL;DR: Using the retroviral vector MFG in conjunction with short-term culture techniques, the mean transduction efficiency in primary renal, ovarian, and pancreatic tumor explants is achieved, and an autologous granulocyte-macrophage colony-stimulating factor secreting tumor vaccine is developed for clinical trials.
Journal Article
Consistent Chromosome Abnormalities in Adenocarcinoma of the Pancreas
Constance A. Griffin,Ralph H. Hruban,Laura Morsberger,T. Ellingham,Patricia P. Long,Elizabeth M. Jaffee,Karen M. Hauda,Stefan K. Bohlander,Charles J. Yeo +8 more
TL;DR: In this paper, the authors studied 62 primary pancreatic adenocarcinomas obtained from surgical resections using classical cytogenetics and fluorescent in situ hybridization methods and found that the most frequent whole chromosomal gains were chromosomes 20 (eight tumors) and 7 (seven tumors).
Journal ArticleDOI
Phase I Study of Non-Replicating Autologous Tumor Cell Injections Using Cells Prepared With or Without GM-CSF Gene Transduction in Patients with Metastatic Renal Cell Carcinoma
Investigators: Anton J. M. Berns,Shirley Clift,Lawrence K. Cohen,Ross C. Donehower,Glenn Dranoff,Karen M. Hauda,Elizabeth M. Jaffee,Audrey J. Lazenby,Hyam I. Levitsky,Fray F. Marshall,Richard C. Mulligan,William G. Nelson,Albert H. Owens,Drew M. Pardoll,Gordon Parry,Alan H. Partin,Steven Piantadosi,Jonathan W. Simons,James Zabora,Principal InvestigatorJonathan W. Simons +19 more
Journal ArticleDOI
Enhanced immune priming with spatial distribution of paracrine cytokine vaccines
Elizabeth M. Jaffee,Matthew C. Thomas,Alex Yee-Chen Huang,Karen M. Hauda,Hyam I. Levitsky,Drew M. Pardoll +5 more
TL;DR: The murine model is used to identify a number of parameters that may be critical for enhancing vaccine efficacy, including antigen dose and cytokine level, and the distribution of vaccine inoculation was found to have a significant impact on vaccine potency.