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Karen R. Cleary
Researcher at University of Texas MD Anderson Cancer Center
Publications - 158
Citations - 20952
Karen R. Cleary is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Adenocarcinoma & Metastasis. The author has an hindex of 67, co-authored 158 publications receiving 20453 citations. Previous affiliations of Karen R. Cleary include University of Texas Health Science Center at Houston & University of Florida.
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Journal ArticleDOI
Mutations in the p53 gene occur in diverse human tumour types
Janice M. Nigro,Suzanne J. Baker,Antonette C. Preisinger,J M Jessup,R. Hostetter,Karen R. Cleary,S H Bigner,Nancy E. Davidson,Stephen B. Baylin,Peter Devilee +9 more
TL;DR: It is suggested that most tumours with allelic deletions of chromosome 17p contain p53 point mutations resulting in amino-acid substitutions, and p53 gene mutations are clustered in four 'hot-spots' which exactly coincide with the four most highly conserved regions of the gene.
Journal Article
Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.
TL;DR: The hypothesis that VEGF is an important angiogenic factor in primary and metastatic human colon cancer is supported and expression and vessel counts may aid in predicting patients at risk for metastasis from colon cancer.
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Preoperative Gemcitabine-Based Chemoradiation for Patients With Resectable Adenocarcinoma of the Pancreatic Head
Douglas B. Evans,Gauri R. Varadhachary,Christopher H. Crane,Charlotte C. Sun,Jeffrey E. Lee,Peter W.T. Pisters,Jean Nicolas Vauthey,Huamin Wang,Karen R. Cleary,Gregg A Staerkel,Chusilp Charnsangavej,Elizabeth A. Lano,Linus Ho,Renato Lenzi,James L. Abbruzzese,Robert A. Wolff +15 more
TL;DR: The encouraging overall survival observed in this large trial supports the continued investigation of gemcitabine-based preoperative therapy in resectable pancreatic cancer.
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Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas.
Douglas B. Evans,Tyvin A. Rich,David R. Byrd,Karen R. Cleary,John H. Connelly,Bernard Levin,Chusilp Charnsangavej,Claudia J. Fenoglio,Frederick C. Ames +8 more
TL;DR: The results suggest that pancreaticoduodenectomy can be performed with a low incidence of complications after chemoradiation for localized adenocarcinoma of the pancreas.
Journal ArticleDOI
Simplified Staging for Hepatocellular Carcinoma
Jean Nicolas Vauthey,Gregory Y. Lauwers,Nestor F. Esnaola,Kim Anh Do,Jacques Belghiti,Nadeem Q. Mirza,Steven A. Curley,Lee M. Ellis,Jean Marc Regimbeau,Asif Rashid,Karen R. Cleary,David M. Nagorney +11 more
TL;DR: The current AJCC staging system for HCC is unnecessarily complex and a simplified model of stratification is proposed based on vascular invasion, tumor number, and tumor size and incorporates the effect of fibrosis on survival.