K
Karen R. Fitch
Researcher at Thermo Fisher Scientific
Publications - 2
Citations - 4486
Karen R. Fitch is an academic researcher from Thermo Fisher Scientific. The author has contributed to research in topics: Copy-number variation & International HapMap Project. The author has an hindex of 2, co-authored 2 publications receiving 4314 citations. Previous affiliations of Karen R. Fitch include University of Tokyo.
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Journal ArticleDOI
Global variation in copy number in the human genome
Richard Redon,Shumpei Ishikawa,Karen R. Fitch,Lars Feuk,George H. Perry,T. Daniel Andrews,Heike Fiegler,Michael H. Shapero,Andrew R. Carson,Wenwei Chen,Eun Kyung Cho,Stephanie Dallaire,Jennifer L. Freeman,Juan R. González,Mònica Gratacòs,Jing Huang,Dimitrios Kalaitzopoulos,Daisuke Komura,Jeffrey R. MacDonald,Christian R. Marshall,Rui Mei,Lyndal Montgomery,Keunihiro Nishimura,Kohji Okamura,Fan Shen,Martin J. Somerville,Joelle Tchinda,Armand Valsesia,Cara Woodwark,Fengtang Yang,Junjun Zhang,Tatiana Zerjal,Jane Zhang,Lluís Armengol,Donald F. Conrad,Xavier Estivill,Chris Tyler-Smith,Nigel P. Carter,Hiroyuki Aburatani,Charles Lee,Keith W. Jones,Stephen W. Scherer,Matthew E. Hurles +42 more
TL;DR: A first-generation CNV map of the human genome is constructed through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia, underscoring the importance of CNV in genetic diversity and evolution and the utility of this resource for genetic disease studies.
Journal ArticleDOI
Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arrays
Daisuke Komura,Fan Shen,Shumpei Ishikawa,Karen R. Fitch,Wenwei Chen,Jane Zhang,Guoying Liu,Sigeo Ihara,Hiroshi Nakamura,Matthew E. Hurles,Charles Lee,Stephen W. Scherer,Keith W. Jones,Michael H. Shapero,Jing Huang,Hiroyuki Aburatani +15 more
TL;DR: A novel algorithm is described using Affymetrix GeneChip Human Mapping 500K Early Access (500K EA) arrays that identified 1203 CNVs ranging in size from 960 bp to 3.4 Mb and demonstrated a >90% verification rate.