Karima Brahimi

TL;DR: The findings suggest that sterile immunity and clinical protection are never fully achieved in humans continuously exposed since birth to intense transmission.

TL;DR: In chimpanzees (Pan troglodytes), the primates most closely related to humans and that share a similar susceptibility to P. falciparum liver-stage infection, immunization with LSA-3 induced protection against successive heterologous challenges with large numbers of P. Falcons sporozoites.

TL;DR: The results suggest that relatively large synthetic peptides, carefully chosen from pertinent areas of proteins and incorporating a simple palmitoyllysine, can induce not only CTL, but also strong Th and antibody responses in genetically diverse populations.

TL;DR: Results support the assertion that immune responses to LS Ag are involved in protection against malaria pre-erythrocytic stages and support the recent finding of conserved CTL epitopes in LSA-1.

TL;DR: It is demonstrated that mosquito bites and very likely saliva rapidly trigger the immune system, emphasizing the critical contribution of peripheral mast cells in inducing T cell and dendritic cell recruitment within draining lymph nodes, a prerequisite for the elicitation of T and B lymphocyte priming.