K
Karin Neubert
Researcher at University of Freiburg
Publications - 4
Citations - 615
Karin Neubert is an academic researcher from University of Freiburg. The author has contributed to research in topics: Signal transduction & Apoptosis. The author has an hindex of 4, co-authored 4 publications receiving 591 citations.
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Journal ArticleDOI
Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane
TL;DR: The COOH-terminal region of Bcl-2 can be converted into a targeting signal for the MOM by increasing the basicity surrounding its TM, and it is proposed that B cl-2 acts on several intracellular membranes whereas BCl-xL specifically functions on the Mom.
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Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways
Ursula Klingmüller,Alexander Bauer,Sebastian Bohl,P. J. Nickel,Katja Breitkopf,Steven Dooley,Sebastian Zellmer,Claudia Kern,Irmgard Merfort,Titus Sparna,Johannes Donauer,Gerd Walz,Marcel Geyer,Clemens Kreutz,Matthias Hermes,Frank Götschel,Andreas Hecht,Dorothee Walter,Lotti Egger,Karin Neubert,Christoph Borner,Marc Brulport,Wiebke Schormann,C. Sauer,F. Baumann,R. Preiss,Sabine MacNelly,Patricio Godoy,Eliza Wiercinska,L. Ciuclan,Jeanett Edelmann,Katrin Zeilinger,M. Heinrich,Ulrich M. Zanger,Rolf Gebhardt,Thomas Maiwald,R. Heinrich,Jens Timmer,F. von Weizsäcker,Jan G. Hengstler +39 more
TL;DR: The mouse hepatocyte in vitro system provides an important basis for the generation of high-quality quantitative data under standardised cell culture conditions that is essential to elucidate critical hepatocellular functions by the systems biology approach.
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Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes
Karine Sá Ferreira,Clemens Kreutz,Sabine MacNelly,Karin Neubert,Angelika Haber,Matthew Bogyo,Jens Timmer,Christoph Borner +7 more
TL;DR: A previously published model predicted a positive feedback loop between active caspases-3 and -8 in both type I and type II FasL signaling in lymphocytes and Hela cells, respectively and this hypothesis is experimentally tested in the hepatocytic type I Fas signaling pathway by using wild-type and XIAP-deficient primary hepatocytes and two recently characterized, selective caspase-3/-7 inhibitors.
Journal ArticleDOI
Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes
Dorothee Walter,Kathrin Schmich,Sandra Vogel,Robert Pick,Thomas Kaufmann,Florian Christoph Hochmuth,Angelika Haber,Karin Neubert,Sabine McNelly,Fritz von Weizsäcker,Irmgard Merfort,Ulrich Maurer,Andreas Strasser,Christoph Borner +13 more
TL;DR: The data suggest a selective crosstalk between extracellular matrix and Fas‐mediated signaling that favors mitochondria‐independent type I apoptosis induction.