K
Katrin Zeilinger
Researcher at Charité
Publications - 86
Citations - 3167
Katrin Zeilinger is an academic researcher from Charité. The author has contributed to research in topics: Stem cell & Liver cell. The author has an hindex of 31, co-authored 86 publications receiving 2867 citations. Previous affiliations of Katrin Zeilinger include Humboldt University of Berlin & Humboldt State University.
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Journal ArticleDOI
HepaRG Human Hepatic Cell Line Utility as a Surrogate for Primary Human Hepatocytes in Drug Metabolism Assessment in Vitro
Marc Lübberstedt,Ursula Müller-Vieira,Manuela Mayer,Klaus M. Biemel,Fanny Knöspel,Daniel Knobeloch,Andreas K. Nussler,Jörg C. Gerlach,Jörg C. Gerlach,Katrin Zeilinger +9 more
TL;DR: The results from this study indicate that HepaRG cells could provide a suitable alternative to pHH in pharmaceutical research and development for metabolism studies such as CYP induction or sub-chronic to chronic hepatotoxicity studies.
Journal ArticleDOI
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.
Natalie Alépée,Anthony Bahinski,Mardas Daneshian,Bart De Wever,Ellen Fritsche,Alan M. Goldberg,Jan Hansmann,Thomas Hartung,John W. Haycock,Helena T. Hogberg,Lisa Hoelting,Jens M. Kelm,Suzanne Kadereit,Emily A. McVey,Robert Landsiedel,Marcel Leist,Marc Lübberstedt,Fozia Noor,Christian Pellevoisin,Dirk Petersohn,Uwe Pfannenbecker,Kerstin Reisinger,Tzutzuy Ramirez,Barbara Rothen-Rutishauser,Monika Schäfer-Korting,Katrin Zeilinger,Marie Gabriele Zurich +26 more
TL;DR: This review summarizes the state of the art concerning commonalities of the different models and indicates a roadmap for the successful implementation of 3D models in routine screening.
Journal ArticleDOI
Cell sources for in vitro human liver cell culture models.
TL;DR: This review gives an overview of the major human cell sources under investigation for in vitro liver cell culture models, including primary human liver cells, liver cell lines, and stem cells.
Journal ArticleDOI
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways
Ursula Klingmüller,Alexander Bauer,Sebastian Bohl,P. J. Nickel,Katja Breitkopf,Steven Dooley,Sebastian Zellmer,Claudia Kern,Irmgard Merfort,Titus Sparna,Johannes Donauer,Gerd Walz,Marcel Geyer,Clemens Kreutz,Matthias Hermes,Frank Götschel,Andreas Hecht,Dorothee Walter,Lotti Egger,Karin Neubert,Christoph Borner,Marc Brulport,Wiebke Schormann,C. Sauer,F. Baumann,R. Preiss,Sabine MacNelly,Patricio Godoy,Eliza Wiercinska,L. Ciuclan,Jeanett Edelmann,Katrin Zeilinger,M. Heinrich,Ulrich M. Zanger,Rolf Gebhardt,Thomas Maiwald,R. Heinrich,Jens Timmer,F. von Weizsäcker,Jan G. Hengstler +39 more
TL;DR: The mouse hepatocyte in vitro system provides an important basis for the generation of high-quality quantitative data under standardised cell culture conditions that is essential to elucidate critical hepatocellular functions by the systems biology approach.
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Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study.
Jörg C. Gerlach,Kerim Mutig,Igor M. Sauer,Petra Schrade,Ekaterina Efimova,T Mieder,Götz Naumann,A Grünwald,Gesine Pless,Antoni Mas,Sebastian Bachmann,Peter Neuhaus,Katrin Zeilinger +12 more
TL;DR: The results show that primary human liver cells obtained from discarded donor organs recover and can be maintained in bioreactors for clinical liver support therapy.