K
Karl Stefic
Researcher at François Rabelais University
Publications - 44
Citations - 1774
Karl Stefic is an academic researcher from François Rabelais University. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 10, co-authored 31 publications receiving 793 citations. Previous affiliations of Karl Stefic include French Institute of Health and Medical Research.
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Journal ArticleDOI
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies.
Delphine Planas,Delphine Planas,Timothée Bruel,Timothée Bruel,Ludivine Grzelak,Florence Guivel-Benhassine,Florence Guivel-Benhassine,Isabelle Staropoli,Isabelle Staropoli,Françoise Porrot,Françoise Porrot,Cyril Planchais,Julian Buchrieser,Julian Buchrieser,Maaran Michael Rajah,Elodie Bishop,Mélanie Albert,Mélanie Albert,Flora Donati,Flora Donati,Matthieu Prot,Sylvie Behillil,Sylvie Behillil,Vincent Enouf,Vincent Enouf,Marianne Maquart,Mounira Smati-Lafarge,Emmanuelle Varon,Frédérique Schortgen,Layla Yahyaoui,María González,Jérôme De Seze,Hélène Péré,David Veyer,Aymeric Sève,Etienne Simon-Loriere,Samira Fafi-Kremer,Karl Stefic,Hugo Mouquet,Laurent Hocqueloux,Sylvie van der Werf,Sylvie van der Werf,Thierry Prazuck,Olivier Schwartz,Olivier Schwartz +44 more
TL;DR: In this paper, the sensitivity of the two variants to SARS-CoV-2 antibodies present in sera and nasal swabs from individuals infected with previously circulating strains or who were recently vaccinated, in comparison with a D614G reference virus was examined.
Journal ArticleDOI
Follow-up of adults with noncritical COVID-19 two months after symptom onset.
Claudia Carvalho-Schneider,E. Laurent,Adrien Lemaignen,Emilie Beaufils,Céline Bourbao-Tournois,Said Laribi,Thomas Flament,Nicole Ferreira-Maldent,Franck Bruyère,Karl Stefic,Catherine Gaudy-Graffin,Leslie Grammatico-Guillon,Louis Bernard +12 more
TL;DR: Up to 2 months after symptom onset, two thirds of adults with non-critical CO VID-19 had complaints, mainly anosmia/ageusia, dyspnea or asthenia, and a prolonged medical follow-up of patients with COVID-19 seems essential.
Journal ArticleDOI
Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69-V70, France, August to December 2020.
Antonin Bal,Gregory Destras,Alexandre Gaymard,Karl Stefic,Julien Marlet,Sébastien Eymieux,Hadrien Regue,Quentin Semanas,Constance d’Aubarede,Geneviève Billaud,Frédéric Laurent,Claudia González,Yahia Mekki,Martine Valette,Maude Bouscambert,Catherine Gaudy-Graffin,Bruno Lina,Florence Morfin,Laurence Josset +18 more
TL;DR: In this article, the first detection of variant of concern 202012/01 (VOC) in France (21 December 2020) was reported, where the spike deletion H69-V70 (ΔH69/ΔV70), identified in certain SARS-CoV-2 variants including VOC, is screened for.
Journal ArticleDOI
The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism.
Hélène Blasco,C Bessy,Laurent Plantier,Antoine Lefèvre,Eric Piver,Louis Bernard,Julien Marlet,Karl Stefic,Isabelle Benz-de Bretagne,P Cannet,H Lumbu,T Morel,P Boulard,Christian R. Andres,Patrick Vourc'h,Olivier Herault,Antoine Guillon,Patrick Emond +17 more
TL;DR: The role of the tryptophan-nicotinamide pathway clearly linked to inflammatory signals and microbiota, and the involvement of cytosine, previously described as a coordinator of cell metabolism in SARS-CoV-2, are highlighted, which could open new therapeutic perspectives as indirect targets.
Posted ContentDOI
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies
Delphine Planas,Timothée Bruel,Ludivine Grzelak,Ludivine Grzelak,Florence Guivel-Benhassine,Isabelle Staropoli,Françoise Porrot,Cyril Planchais,Julian Buchrieser,Maaran Michael Rajah,Maaran Michael Rajah,Elodie Bishop,Elodie Bishop,Mélanie Albert,Mélanie Albert,Flora Donati,Flora Donati,Sylvie Behillil,Sylvie Behillil,Vincent Enouf,Vincent Enouf,Marianne Maquart,María González,Jérôme De Seze,Hélène Péré,David Veyer,Aymeric Sève,Etienne Simon-Loriere,Samira Fafi-Kremer,Karl Stefic,Hugo Mouquet,Laurent Hocqueloux,Sylvie van der Werf,Sylvie van der Werf,Thierry Prazuck,Olivier Schwartz +35 more
TL;DR: In this paper, the authors isolated infectious SARS-CoV-2 B.1.7 and B.351 strains and examined their sensitivity to anti-SARS CoV2 antibodies present in sera and nasal swabs, in comparison with a D614G reference virus.