K
Karla F. Meza-Sosa
Researcher at National Autonomous University of Mexico
Publications - 17
Citations - 1150
Karla F. Meza-Sosa is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 10 publications receiving 517 citations. Previous affiliations of Karla F. Meza-Sosa include Harvard University & Boston Children's Hospital.
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Journal ArticleDOI
Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Zhibin Zhang,Zhibin Zhang,Ying Zhang,Ying Zhang,Shiyu Xia,Shiyu Xia,Qing Kong,Shunying Li,Xing Liu,Xing Liu,Xing Liu,Caroline Junqueira,Caroline Junqueira,Caroline Junqueira,Karla F. Meza-Sosa,Karla F. Meza-Sosa,Karla F. Meza-Sosa,Temy Mo Yin Mok,Temy Mo Yin Mok,Temy Mo Yin Mok,James Ansara,James Ansara,Satyaki Sengupta,Yandan Yao,Hao Wu,Hao Wu,Judy Lieberman,Judy Lieberman +27 more
TL;DR: The gasdermin E protein is shown to act as a tumour suppressor: it is cleaved by caspase 3 and granzyme B and leads to pyroptosis of cancer cells, provoking an immune response to the tumour.
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microRNAs: key triggers of neuronal cell fate.
TL;DR: The mechanisms of action of these two sets of microRNAs are reviewed and their functional implications during the transition from neural stem cells and neural progenitors to fully differentiated neurons are reviewed.
Journal ArticleDOI
Role of microRNAs in central nervous system development and pathology
TL;DR: Recent findings on the role that miRNAs play in the development of the CNS as well as in neuropathologies such as schizophrenia, Parkinson disease, and Alzheimer's disease, among others are reviewed.
Journal ArticleDOI
Negative regulation of the inflammasome: keeping inflammation under control.
Gustavo Pedraza-Alva,Leonor Pérez-Martínez,Laura Valdez-Hernández,Karla F. Meza-Sosa,Masami Ando-Kuri +4 more
TL;DR: Recent advances in understanding of the molecular mechanisms that negatively regulate inflammasome activation to prevent unwanted activation in the resting state are reviewed, as well as those involved in terminating the inflammatory response after a specific insult to maintain homeostasis.
Journal ArticleDOI
PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs
Xing Liu,Xing Liu,Rui Fu,Rui Fu,Youdong Pan,Karla F. Meza-Sosa,Karla F. Meza-Sosa,Zhibin Zhang,Zhibin Zhang,Judy Lieberman,Judy Lieberman +10 more
TL;DR: PNPT1 release from mitochondria during MOMP initiates apoptotic decay of RNAs lacking 3'-structures, triggering extensive decay of mRNAs and poly(A) noncoding (nc)RNAs at the 3' end, triggered by the mitochondrial intermembrane space 3'-to-5' exoribonuclease PN PT1.