K
Karly C. Sourris
Researcher at Monash University
Publications - 45
Citations - 2066
Karly C. Sourris is an academic researcher from Monash University. The author has contributed to research in topics: Diabetes mellitus & Glycation. The author has an hindex of 20, co-authored 40 publications receiving 1722 citations. Previous affiliations of Karly C. Sourris include Alfred Hospital & Baker IDI Heart and Diabetes Institute.
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Journal ArticleDOI
RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes
Melinda T. Coughlan,David R. Thorburn,Sally A. Penfold,Sally A. Penfold,Adrienne Laskowski,Brooke E. Harcourt,Brooke E. Harcourt,Karly C. Sourris,Karly C. Sourris,Adeline L.Y. Tan,Adeline L.Y. Tan,Kei Fukami,Vicki Thallas-Bonke,Peter P. Nawroth,Michael Brownlee,Angelika Bierhaus,Mark E. Cooper,Mark E. Cooper,Josephine M. Forbes,Josephine M. Forbes +19 more
TL;DR: It is suggested that AGE-RAGE-induced cytosolic ROS production facilitates mitochondrial superoxide production in hyperglycemic environments, providing further evidence of a role for the advanced glycation pathway in the development and progression of diabetic nephropathy.
Journal ArticleDOI
Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway.
Vicki Thallas-Bonke,Suzanne R. Thorpe,Melinda T. Coughlan,Kei Fukami,Felicia Y. T. Yap,Karly C. Sourris,Sally A. Penfold,Leon A. Bach,Mark E. Cooper,Josephine M. Forbes +9 more
TL;DR: It is concluded that activation of NADPH oxidase via phosphorylation of PKC-α is downstream of the AGE–receptor for AGE interaction in diabetic renal disease and may provide a novel therapeutic target for diabetic nephropathy.
Journal ArticleDOI
Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy
Adeline L.Y. Tan,Karly C. Sourris,Brooke E. Harcourt,Brooke E. Harcourt,Vicki Thallas-Bonke,Sally A. Penfold,Sofianos Andrikopoulos,Merlin C. Thomas,Richard C O'Brien,Angelika Bierhaus,Mark E. Cooper,Mark E. Cooper,Josephine M. Forbes,Josephine M. Forbes,Melinda T. Coughlan +14 more
TL;DR: Diverse approaches to block the AGE-RAGE axis had disparate effects on DN, which has potential clinical implications for the way this axis should be targeted in humans.
Journal ArticleDOI
Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes
Karly C. Sourris,Karly C. Sourris,Brooke E. Harcourt,Brooke E. Harcourt,Peter H. Tang,Amy L. Morley,Karina Huynh,Karina Huynh,Sally A. Penfold,Melinda T. Coughlan,Melinda T. Coughlan,Mark E. Cooper,Mark E. Cooper,Tuong-Vi Nguyen,Rebecca H. Ritchie,Rebecca H. Ritchie,Josephine M. Forbes,Josephine M. Forbes +17 more
TL;DR: The results suggest that a deficiency in mitochondrial oxidized CoQ10 (ubiquinone) may be a likely precipitating factor for diabetic nephropathy, and coQ10 supplementation may be renoprotective in type 2 diabetes, via preservation of mitochondrial function.
Journal ArticleDOI
Targeted reduction of advanced glycation improves renal function in obesity
Brooke E. Harcourt,Karly C. Sourris,Melinda T. Coughlan,Karen Z. Walker,Sonia L Dougherty,Sofianos Andrikopoulos,Amy L. Morley,Vicki Thallas-Bonke,Vibhasha Chand,Sally A. Penfold,Maximilian de Courten,Merlin C. Thomas,Bronwyn A. Kingwell,Angelika Bierhaus,Mark E. Cooper,Barbora de Courten,Josephine M. Forbes +16 more
TL;DR: Renal function and an inflammatory profile were improved following the low-AGE diet and treatment of the RAGE knockout mice with alagebrium improved urinary albumin excretion, creatinine clearance, the inflammatory profile, and renal oxidative stress.