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Showing papers by "Kassoum Kayentao published in 2008"

Journal Article•DOI•
Sickle Cell Trait is Associated with a Delayed Onset of Malaria: Implications for Time-to-Event Analysis in Clinical Studies of Malaria

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Peter D. Crompton1, Boubacar Traore2, Kassoum Kayentao2, Safiatou Doumbo2, Aissata Ongoiba2, Seidina A. S. Diakite2, Michael Krause1, Didier Doumtabe2, Younoussou Kone2, Greta E Weiss1, Chiung Yu Huang1, Seydou Doumbia2, Aldiouma Guindo2, Rick M. Fairhurst1, Louis H. Miller1, Susan K. Pierce1, Ogobara K. Doumbo2 •
National Institutes of Health1, University of Bamako2
01 Nov 2008-The Journal of Infectious Diseases
TL;DR: It would be advisable for clinical trials and observational studies that use this end point to include Hb typing in the design of studies conducted in areas where HbAS is prevalent, given the delay in the time to first malaria episode associated with Hb AS.
Abstract: Background The World Health Organization (WHO) recently recommended that the time to first malaria episode serve as the primary endpoint in phase III malaria vaccine trials—the first of which will be held in Africa. Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (Hb) S are known to protect against malaria in Africa, their impact on this endpoint has not been investigated.

118 citations