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Younoussou Kone
Researcher at University of the Sciences
Publications - 8
Citations - 986
Younoussou Kone is an academic researcher from University of the Sciences. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 7, co-authored 8 publications receiving 912 citations. Previous affiliations of Younoussou Kone include University of Bamako.
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Journal ArticleDOI
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray.
Peter D. Crompton,Matthew A. Kayala,Boubacar Traore,Kassoum Kayentao,Aissata Ongoiba,Greta E Weiss,Douglas M. Molina,Chad Burk,Michael Waisberg,Algis Jasinskas,Xiaolin Tan,Safiatou Doumbo,Didier Doumtabe,Younoussou Kone,David L. Narum,Xiaowu Liang,Ogobara K. Doumbo,Louis H. Miller,Denise L. Doolan,Pierre Baldi,Philip L. Felgner,Susan K. Pierce +21 more
TL;DR: A protein microarray was developed and used to probe plasma from 220 individuals in Mali and provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features, which could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf.
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The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections
Greta E Weiss,Boubacar Traore,Kassoum Kayentao,Aissata Ongoiba,Safiatou Doumbo,Didier Doumtabe,Younoussou Kone,Seydou Dia,Agnes Guindo,Abdramane Traore,Chiung Yu Huang,Kazutoyo Miura,Marko Mircetic,Shanping Li,Amy W. Baughman,David L. Narum,Louis H. Miller,Ogobara K. Doumbo,Susan K. Pierce,Peter D. Crompton +19 more
TL;DR: It is shown that Pf-specific memory B-cells and antibodies are acquired gradually in a stepwise fashion over years of repeated Pf exposure, based on the comparator response to tetanus vaccination that was efficient and stable.
Journal ArticleDOI
Sickle Cell Trait is Associated with a Delayed Onset of Malaria: Implications for Time-to-Event Analysis in Clinical Studies of Malaria
Peter D. Crompton,Boubacar Traore,Kassoum Kayentao,Safiatou Doumbo,Aissata Ongoiba,Seidina A. S. Diakite,Michael Krause,Didier Doumtabe,Younoussou Kone,Greta E Weiss,Chiung Yu Huang,Seydou Doumbia,Aldiouma Guindo,Rick M. Fairhurst,Louis H. Miller,Susan K. Pierce,Ogobara K. Doumbo +16 more
TL;DR: It would be advisable for clinical trials and observational studies that use this end point to include Hb typing in the design of studies conducted in areas where HbAS is prevalent, given the delay in the time to first malaria episode associated with Hb AS.
Journal ArticleDOI
In Vitro Growth-Inhibitory Activity and Malaria Risk in a Cohort Study in Mali
Peter D. Crompton,Kazutoyo Miura,Boubacar Traore,Kassoum Kayentao,Aissata Ongoiba,Greta E Weiss,Safiatou Doumbo,Didier Doumtabe,Younoussou Kone,Chiung Yu Huang,Ogobara K. Doumbo,Louis H. Miller,Carole A. Long,Susan K. Pierce +13 more
TL;DR: It is suggested that antibodies which block merozoite invasion of RBC and/or inhibit the intra-RBC growth of the parasite contribute to but are not sufficient for the acquisition of malaria immunity.
Journal ArticleDOI
Treatment of Chronic Asymptomatic Plasmodium falciparum Infection Does Not Increase the Risk of Clinical Malaria Upon Reinfection.
Silvia Portugal,Tuan M. Tran,Tuan M. Tran,Aissata Ongoiba,Aboudramane Bathily,Shanping Li,Safiatou Doumbo,Jeff Skinner,Didier Doumtabe,Younoussou Kone,Jules Sangala,Aarti Jain,D. Huw Davies,Christopher Hung,Li Liang,Stacy Ricklefs,Manijeh Vafa Homann,Philip L. Felgner,Stephen F. Porcella,Anna Färnert,Ogobara K. Doumbo,Kassoum Kayentao,Brian Greenwood,Boubacar Traore,Peter D. Crompton +24 more
TL;DR: This article showed that chronic asymptomatic P. falciparum infection predicted decreased clinical malaria risk during the subsequent malaria season(s); treatment of these infections did not alter this reduced risk.