Peter D. Crompton

TL;DR: It is shown that chronic malaria drives specific T cell dysfunction, and proper function can be restored by inhibitory therapies to enhance parasite control.

TL;DR: A protein microarray was developed and used to probe plasma from 220 individuals in Mali and provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features, which could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf.

TL;DR: Evidence is provided that a phenotypically similar atypical MBC population is significantly expanded in Pf-exposed Malian adults and children as young as 2 years of age as compared with healthy U.S. adult controls.

TL;DR: A better understanding of the mechanisms of naturally acquired immunity to malaria may lead to insights for vaccine development, and new vaccine targets need to be identified to improve the chances of developing a highly effective malaria vaccine.

TL;DR: It is demonstrated that vaccination against α-gal confers sterile protection against malaria in mice, suggesting that a similar approach may reduce malaria transmission in humans.