Katarzyna Kida

TL;DR: Eight proteins, defects in which are associated with Meckel-Gruber syndrome and nephronophthisis ciliopathies, work together as two functional modules at the transition zone to establish basal body/transition zone connections with the membrane and barricade entry of non-ciliary components into this organelle.

TL;DR: The small GTPase Arl13b regulates ciliary transmembrane protein localizations and anterograde IFT assembly stability.

TL;DR: It is shown that a network containing Rac1, RhoA, and PAK family kinases can produce bistable, switch-like responses to a graded PAK inhibition, and that PAK is a critical component in the Rac1-RhoA inhibitory crosstalk that governs bistables GTPase activity, cell morphology, and cell migration switches.

TL;DR: The transport mechanisms underlying compartmentalization of JS-associated ARL13B/ARL-13, which was previously found is restricted at proximal ciliary membranes are investigated, reveal distinct requirements for sequence motifs, IFT and ciliopathy modules in defining an ARL- 13 subciliary membrane compartment.

TL;DR: These data implicate C. elegans endocytosis proteins localized at the ciliary base in regulating ciliary and periciliary membrane volume and suggest that membrane retrieval from these compartments is counterbalanced by BBS-8 and RAB-8-mediated membrane delivery.