K
Katarzyna Szarc vel Szic
Researcher at University of Antwerp
Publications - 15
Citations - 712
Katarzyna Szarc vel Szic is an academic researcher from University of Antwerp. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 12, co-authored 15 publications receiving 605 citations. Previous affiliations of Katarzyna Szarc vel Szic include Ghent University & Flemish Institute for Technological Research.
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Journal ArticleDOI
From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
TL;DR: The epigenetic actions of dietary components, including phytochemicals, and macro- and micronutrients as well as metabolites, that can attenuate inflammaging are summarized.
Journal ArticleDOI
Nature or nurture: Let food be your epigenetic medicine in chronic inflammatory disorders
Katarzyna Szarc vel Szic,Matladi N. Ndlovu,Matladi N. Ndlovu,Guy Haegeman,Wim Vanden Berghe,Wim Vanden Berghe +5 more
TL;DR: Re-exploration of anti-inflammatory bioactive food components for characterization of their effects on epigenome modifying enzymatic activities may allow to improve healthy aging by reversing disease prone epimutations involved in chronic inflammatory and metabolic disorders.
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Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells
Katarzyna Szarc vel Szic,Ken Op de Beeck,Dariusz Ratman,An Wouters,Ilse M. Beck,Ken Declerck,Karen Heyninck,Erik Fransen,Marc Bracke,Karolien De Bosscher,Filip Lardon,Guy Van Camp,Wim Vanden Berghe +12 more
TL;DR: Taking into account that sub-cytotoxic concentrations of WA target multiple metastatic effectors in therapy-resistant triple negative breast cancer, WA-based therapeutic strategies targeting the uPA pathway hold promise for further (pre)clinical development to defeat aggressive metastatic breast cancer.
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Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State
Dragan Milenkovic,Wim Vanden Berghe,Céline Boby,Christine Leroux,Ken Declerck,Katarzyna Szarc vel Szic,Karen Heyninck,Kris Laukens,Martin Bizet,Matthieu Defrance,Sarah Dedeurwaerder,Emilie Calonne,François Fuks,Guy Haegeman,Guido R.M.M. Haenen,Aalt Bast,Antje R. Weseler +16 more
TL;DR: It is revealed that an 8 week daily supplementation with 200 mg MOF modulates the expression of genes associated with cardiovascular disease pathways without major changes of their DNA methylation state, however, strong inter-individual variation in leukocyte DNAmethylation may obscure the subtle epigenetic response to dietary flavanols.
Journal ArticleDOI
Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.
Karen Heyninck,Linde Sabbe,Chandra Sekhar Chirumamilla,Katarzyna Szarc vel Szic,Pieter Van der Veken,Kristien J.A. Lemmens,Maija Lahtela-Kakkonen,Stefan Naulaerts,Ken Op de Beeck,Kris Laukens,Guy Van Camp,Antje R. Weseler,Aalt Bast,Guido R.M.M. Haenen,Guy Haegeman,Wim Vanden Berghe +15 more
TL;DR: It is demonstrated that WA time- and concentration-dependently induces HO-1 expression in endothelial cells via upregulation and increased nuclear translocation of Nrf2.