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Sarah Dedeurwaerder
Researcher at Université libre de Bruxelles
Publications - 23
Citations - 2198
Sarah Dedeurwaerder is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 16, co-authored 23 publications receiving 1895 citations. Previous affiliations of Sarah Dedeurwaerder include University of Picardie Jules Verne & Free University of Brussels.
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Journal ArticleDOI
Evaluation of the Infinium Methylation 450K technology.
Sarah Dedeurwaerder,Matthieu Defrance,Emilie Calonne,Hélène Denis,Christos Sotiriou,François Fuks +5 more
TL;DR: Infinium Methylation 450K is a powerful technique in terms of reagent costs, time of labor, sample throughput and coverage, and holds great promise for the better understanding of the epigenetic component in health and disease.
Journal ArticleDOI
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.
Michael Volkmar,Sarah Dedeurwaerder,Daniel Andrade Da Cunha,Matladi N. Ndlovu,Matthieu Defrance,Rachel Deplus,Emilie Calonne,Ute Volkmar,Mariana Igoillo-Esteve,Najib Naamane,Silvia Del Guerra,Matilde Masini,Marco Bugliani,Piero Marchetti,Miriam Cnop,Miriam Cnop,Decio L. Eizirik,François Fuks +17 more
TL;DR: This study performed the first comprehensive DNA methylation profiling in pancreatic islets from T2D and non‐diabetic donors, uncovering 276 CpG loci affiliated to promoters of 254 genes displaying significant differentialDNA methylation in diabetic islets.
Journal ArticleDOI
Recommendations for the design and analysis of epigenome-wide association studies
Karin B. Michels,Alexandra M. Binder,Sarah Dedeurwaerder,Charles B. Epstein,John M. Greally,Ivo Gut,E. Andres Houseman,Benedetta Izzi,Karl T. Kelsey,Alexander Meissner,Alexander Meissner,Aleksandar Milosavljevic,Kimberly D. Siegmund,Christoph Bock,Christoph Bock,Christoph Bock,Rafael A. Irizarry +16 more
TL;DR: Concepts for conducting a stringent and powerful EWAS are reviewed, including the choice of analyzed tissue, sources of variability and systematic biases, analytical solutions to EWAS-specific problems are outlined and caveats in interpretation of data generated from samples with cellular heterogeneity are highlighted.
Journal ArticleDOI
DNA methylation profiling reveals a predominant immune component in breast cancers.
Sarah Dedeurwaerder,Christine Desmedt,Emilie Calonne,Sandeep Singhal,Benjamin Haibe-Kains,Matthieu Defrance,Stefan Michiels,Michael Volkmar,Rachel Deplus,Judith Luciani,Françoise Lallemand,Denis Larsimont,Jérôme Toussaint,Sandy Haussy,Françoise Rothé,Ghizlane Rouas,Otto Metzger,Samira Majjaj,Kamal S Saini,Pascale Putmans,Gérald Hames,Nicolas van Baren,Pierre Coulie,Martine Piccart,Christos Sotiriou,François Fuks +25 more
TL;DR: The immune component uncovered here by DNA methylation profiles provides a new perspective for the importance of the microenvironment in breast cancer, holding implications for better management of breast cancer patients.
Journal ArticleDOI
A comprehensive overview of Infinium HumanMethylation450 data processing
Sarah Dedeurwaerder,Matthieu Defrance,Martin Bizet,Emilie Calonne,Gianluca Bontempi,François Fuks +5 more
TL;DR: An overview of the general data processing scheme and an evaluation of the different normalization methods available to date are presented to guide the 450K users in their analysis and data interpretation.