K
Kate L. Jeffrey
Researcher at Harvard University
Publications - 34
Citations - 4494
Kate L. Jeffrey is an academic researcher from Harvard University. The author has contributed to research in topics: Epigenetics & Innate immune system. The author has an hindex of 16, co-authored 28 publications receiving 3625 citations. Previous affiliations of Kate L. Jeffrey include Rockefeller University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Protease-Activated Receptor-2 Activating Peptide SLIGRL Inhibits Bacterial Lipopolysaccharide-Induced Recruitment of Polymorphonuclear Leukocytes into the Airways of Mice
TL;DR: It is suggested that PAR2 agonists may be useful therapeutic molecules in pulmonary inflammatory diseases.
Journal ArticleDOI
Beyond receptors and signaling: epigenetic factors in the regulation of innate immunity
Stuti Mehta,Kate L. Jeffrey +1 more
TL;DR: How pathogens have hijacked these mechanisms for their benefit and the potential of small molecules targeting chromatin machinery as a way to boost or subdue the innate immune response in disease are explored.
Journal ArticleDOI
The Speckled Protein (SP) Family: Immunity's Chromatin Readers.
TL;DR: It is posit that SPs are central chromatin regulators of gene silencing that establish immune cell identity and function and are therapeutic targets in cancer and inflammation.
Journal ArticleDOI
A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming.
Arunava Bandyopadhaya,Amy Tsurumi,Amy Tsurumi,Damien Maura,Damien Maura,Kate L. Jeffrey,Laurence G. Rahme,Laurence G. Rahme +7 more
TL;DR: 2-aminoacetophenone induced reprogramming of immune cells occurs via alterations in histone acetylation of immune cytokines in vivo and in vitro, providing the first mechanistic example of a quorum-sensing molecule regulating a host epigenome to enable tolerance of infection.
Journal ArticleDOI
Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.
Stuti Mehta,D. Alexander Cronkite,Megha Basavappa,Tahnee L. Saunders,Fatemeh Adiliaghdam,Hajera Amatullah,Sara A. Morrison,Jose D. Pagan,Robert M. Anthony,Pierre Tonnerre,Georg M. Lauer,James Lee,Sreehaas Digumarthi,Lorena Pantano,Shannan J. Ho Sui,Fei Ji,Ruslan I. Sadreyev,Chan Zhou,Alan C. Mullen,Vinod Kumar,Yang Li,Cisca Wijmenga,Ramnik J. Xavier,Terry K. Means,Kate L. Jeffrey +24 more
TL;DR: It is shown that SP140 is critical for transcriptional programs that uphold the macrophage state, and a loss of SP140 due to genetic variation contributes to a molecularly defined subset of CD characterized by ineffective innate immunity, normally critical for intestinal homeostasis.