K
Kate L. Jeffrey
Researcher at Harvard University
Publications - 34
Citations - 4494
Kate L. Jeffrey is an academic researcher from Harvard University. The author has contributed to research in topics: Epigenetics & Innate immune system. The author has an hindex of 16, co-authored 28 publications receiving 3625 citations. Previous affiliations of Kate L. Jeffrey include Rockefeller University & Massachusetts Institute of Technology.
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Method of diagnosing and treating inflammatory diseases using pac-1 (dusp2)
TL;DR: In this paper, a method for identifying agonists and antagonists of the enzyme PAC-1 (DUSP2) that are useful in the therapeutic methods described in this paper is presented.
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Identification of topoisomerase as a precision-medicine target in chromatin reader SP140-driven Crohn’s disease
Hajera Amatullah,Sreehaas Digumarthi,Isabella Fraschilla,Fatemeh Adiliaghdam,Gracia Bonilla,Lai Ping Wong,Ruslan I. Sadreyev,Kate L. Jeffrey +7 more
TL;DR: The authors identified SP140 as a repressor of topoisomerases and revealed repurposing of TOP inhibition as a precision strategy for reversing SP140-driven immune disease in humans and mice.
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Human enteric viruses shape disease phenotype through divergent innate immunomodulation
Fatemeh Adiliaghdam,Hajera Amatullah,Sreehaas Digumarthi,Tahnee L. Saunders,Raza-Ur Rahman,Lai Ping Wong,Ruslan I. Sadreyev,Lindsay Droit,Jean Paquette,Philippe Goyette,John D. Rioux,John D. Rioux,Richard A. Hodin,Kathie A. Mihindukulasuriya,Scot A. Handley,Kate L. Jeffrey,Kate L. Jeffrey +16 more
TL;DR: In this paper, the authors found that IBD patient VLPs provoked inflammation, which was successfully dampened by healthy IBD VLP-like particles, including enriched Picornovirus Enterovirus B, not previously observed in fecal virome studies.
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Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Shaqed Carasso,Haitham Hajjo,Nadav Ben-Assa,Rawi Naddaf,Noa Mandelbaum,Sigal Pressman,Yehuda Chowers,Tal Gefen,Kate L. Jeffrey,Juan Jofre,Michael J. Coyne,Laurie E. Comstock,Itai Sharon,Naama Geva-Zatorsky +13 more
TL;DR: In this article , the authors analyzed metagenomic samples from six human Inflammatory Bowel Disease (IBD) cohorts combined with mice experimentation, and identified multiple invertible regions in which a particular orientation was correlated with disease.