K
Kate L. Jeffrey
Researcher at Harvard University
Publications - 34
Citations - 4494
Kate L. Jeffrey is an academic researcher from Harvard University. The author has contributed to research in topics: Epigenetics & Innate immune system. The author has an hindex of 16, co-authored 28 publications receiving 3625 citations. Previous affiliations of Kate L. Jeffrey include Rockefeller University & Massachusetts Institute of Technology.
Papers
More filters
Journal ArticleDOI
GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses
Hao-Sen Chiang,Yun Zhao,Joo Hye Song,Song Liu,Ninghai Wang,Cox Terhorst,Arlene H. Sharpe,Megha Basavappa,Kate L. Jeffrey,Hans Christian Reinecker +9 more
TL;DR: It is shown that the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I–like receptors.
Journal ArticleDOI
HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus
Dahlene N. Fusco,Henry Pratt,Stephen Kandilas,Stephen Kandilas,Scarlett Se Yun Cheon,Wenyu Lin,D. Alex Cronkite,Megha Basavappa,Kate L. Jeffrey,Anthony Anselmo,Ruslan I. Sadreyev,Clarence Yapp,Xu Shi,John F. O'Sullivan,Robert E. Gerszten,Robert E. Gerszten,Takuya Tomaru,Satoshi Yoshino,Tetsurou Satoh,Raymond T. Chung +19 more
TL;DR: Overall, these findings reveal that IFN antiviral response is mediated by HELZ2 transcriptional upregulation, enrichment of Helicase With Zinc Finger 2 protein levels in the nucleus, and activation of a transcriptional program that appears to modulate intracellular lipid state.
Journal ArticleDOI
Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.
Tatsuro Murano,Tatsuro Murano,Mehran Najibi,Mehran Najibi,Geraldine L.C. Paulus,Geraldine L.C. Paulus,Fatemeh Adiliaghdam,Aida Valencia-Guerrero,Martin K. Selig,Xiaofei Wang,Kate L. Jeffrey,Ramnik J. Xavier,Ramnik J. Xavier,Kara G. Lassen,Kara G. Lassen,Javier E. Irazoqui,Javier E. Irazoqui +16 more
TL;DR: This study reveals that TFEB is critical for resistance to intestinal epithelial cell injury, potentially mediated by APOA1.
Journal ArticleDOI
A Requirement for Argonaute 4 in Mammalian Antiviral Defense
Fatemeh Adiliaghdam,Megha Basavappa,Tahnee L. Saunders,Dewi Harjanto,John T. Prior,D. Alexander Cronkite,Nina Papavasiliou,Kate L. Jeffrey +7 more
TL;DR: AGO-loaded virus-derived short interfering RNAs (vsiRNAs), a molecular marker of antiviral RNAi, are identified in macrophages infected with influenza or influenza lacking the IFN and RNAi suppressor NS1, which are uniquely diminished without AGO4.
Journal ArticleDOI
Epigenome-metabolome-microbiome axis in health and IBD.
TL;DR: Evidence that the host epigenome plays a significant role in orchestrating the bidirectional crosstalk between mammals and their commensal microorganisms is reviewed and emerging insights into the intricate connection between the microbiome and epigenetic enzyme activity via host or bacterial metabolites are presented.