The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

Regulation of the mevalonate pathway.

https://www.cell.com/cell/pdf/S0092-8674(06)01344-4.pdf

Wnt/beta-catenin signaling in development and disease.

Wnt/β-catenin signaling: components, mechanisms, and diseases

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.

CpG islands in vertebrate genomes.

https://www.salk.edu/pdf/otmd/Jones/S97041/S97041_Cell_1998.pdf

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

https://www.cell.com/trends/biochemical-sciences/pdf/0968-0004(86)90226-4.pdf

Promoter-specific activation of RNA polymerase II transcription by Sp1

https://www.cell.com/cell/pdf/0092-8674(87)90358-8.pdf

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

The nature and position of transcriptional control elements responsible for the expression of genes encoded by the retrovirus associated with acquired immune deficiency syndrome (AIDS) have not been precisely defined. In this study it is shown that the mammalian Sp1 transcription factor binds to promoter sequences within the AIDS retrovirus long terminal repeat (LTR) and activates RNA synthesis five- to eightfold in reconstituted reactions in vitro. Experiments in which regions of DNA were protected from added reagents by specifically bound proteins (footprinting) indicated that the upstream promoter region of the AIDS virus LTR lies between -45 and -77 (relative to the RNA start site, +1) and contains three tandem, closely spaced SP1 binding sites of variable affinity. Base-substitution mutations targeted to one or all three Sp1 binding sites were found both to eliminate the binding of Sp1 and to cause up to a tenfold reduction in transcriptional efficiency in vitro. These findings suggest that one important component of the AIDS virus transcriptional control region interacts with a cellular transcription factor, Sp1, and that this factor must function in conjunction with transcriptional elements located downstream of the RNA cap site to mediate the response of the LTR to viral trans-activation.

http://science.sciencemag.org/content/sci/232/4751/755.full.pdf

Katherine A. Jones

Papers

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

Promoter-specific activation of RNA polymerase II transcription by Sp1

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1

Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro.