K
Kathleen C. Day
Researcher at University of Michigan
Publications - 32
Citations - 2622
Kathleen C. Day is an academic researcher from University of Michigan. The author has contributed to research in topics: Bladder cancer & Prostate cancer. The author has an hindex of 21, co-authored 32 publications receiving 2447 citations. Previous affiliations of Kathleen C. Day include Monsanto & Washington University in St. Louis.
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Journal ArticleDOI
Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging
Ashish Agarwal,Sheng-Wen Huang,Matthew O'Donnell,Kathleen C. Day,Mark L. Day,Nicholas A. Kotov,Shai Ashkenazi +6 more
TL;DR: Combining ultrasound with contrast agent based photoacoustic imaging is proposed as a visual tool to compound molecular and structural information for early stage prostate cancer detection.
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HER2 Drives Luminal Breast Cancer Stem Cells in the Absence of HER2 Amplification: Implications for Efficacy of Adjuvant Trastuzumab
Suthinee Ithimakin,Kathleen C. Day,Fayaz Malik,Qin Zen,Scott J. Dawsey,Tom Bersano-Begey,Ahmed A. Quraishi,Kathleen M. Woods Ignatoski,Stephanie Daignault,April Davis,Christopher L. Hall,Nallasivam Palanisamy,Amber Heath,Nader Tawakkol,Tahra Luther,Shawn G. Clouthier,Whitney A. Chadwick,Mark L. Day,Celina G. Kleer,Dafydd G. Thomas,Daniel F. Hayes,Hasan Korkaya,Max S. Wicha +22 more
TL;DR: It is shown that HER2 is selectively expressed in and regulates self-renewal of the cancer stem cell (CSC) population in estrogen receptor-positive, HER2(-) luminal breast cancers, and a CSC model in which maximal clinical benefit is achieved when CSC targeting agents are administered in the adjuvant setting is supported.
Journal ArticleDOI
Indocyanine-green-embedded PEBBLEs as a contrast agent for photoacoustic imaging.
Gwangseong Kim,Sheng Wen Huang,Kathleen C. Day,Matthew O'Donnell,Rodney R. Agayan,Mark A. Day,Raoul Kopelman,Shai Ashkenazi +7 more
TL;DR: Initial in vitro characterization shows high contrast and high efficiency for binding to prostate cancer cells, and ICG-embedded ormosil PEBBLEs showed improved stability in aqueous solution compared with free ICG dye.
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The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation.
TL;DR: Evidence is provided that ADAM15 catalyzes the cleavage of E-cadherin to generate a soluble fragment that in turn binds to and stimulates ErbB receptor signaling, supporting both cell migration and proliferation.
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The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells.
Jonathan Rios-Doria,Kathleen C. Day,Rainer Kuefer,Michael G. Rashid,Arul M. Chinnaiyan,Mark A. Rubin,Mark L. Day +6 more
TL;DR: A novel mechanism by which E-cadherin is functionally inactivated through calpain-mediated proteolysis is demonstrated and suggests that E- cadher in is targeted by calpain during the tumorigenic progression of prostate cancer.