K
Kathleen C. Flanders
Researcher at National Institutes of Health
Publications - 150
Citations - 19846
Kathleen C. Flanders is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 68, co-authored 150 publications receiving 19278 citations. Previous affiliations of Kathleen C. Flanders include Gyeongsang National University & New York State Department of Health.
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Journal ArticleDOI
Expression of TGF-β signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
Jonine D. Figueroa,Kathleen C. Flanders,Montserrat Garcia-Closas,William F. Anderson,Xiaohong R. Yang,Rayna K. Matsuno,Máire A. Duggan,Ruth M. Pfeiffer,Akira Ooshima,Robert Cornelison,Gretchen L. Gierach,Louise A. Brinton,Jolanta Lissowska,Beata Peplonska,Lalage M. Wakefield,Mark E. Sherman +15 more
TL;DR: Evidence is provided that TGF-β signaling patterns vary by age and pathologic features of prognostic significance including ER expression, which warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment.
Journal ArticleDOI
Altered expression of transforming growth factor‐β1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix
John T. Comerci,Carolyn D. Runowicz,Kathleen C. Flanders,Carol De Victoria,Abbie L. Fields,Anna S. Kadish,Gary L. Goldberg +6 more
TL;DR: Loss of responsiveness to TGF‐β1 or loss of TGF-β1 itself may be important in the progression of cervical intraepithelial neoplasia (CIN) to invasive cervical carcinoma.
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Effects of Transforming Growth Factor-β (Isoforms 1–3) on Amyloid-β Deposition, Inflammation, and Cell Targeting in Organotypic Hippocampal Slice Cultures
Marni E. Harris-White,T. Chu,Zerlinde Balverde,Jason J. Sigel,Kathleen C. Flanders,Sally A. Frautschy +5 more
TL;DR: Important functional differences are demonstrated among the TGF-β isoforms in their ability to alter the cellular distribution and degradation of Aβ, which may be relevant to the pathology of Alzheimer’s disease.
Journal ArticleDOI
Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis.
Giovanni Latella,Antonella Vetuschi,Roberta Sferra,Giuliana Zanninelli,A. D'Angelo,V. Catitti,Renzo Caprilli,Kathleen C. Flanders,Eugenio Gaudio +8 more
TL;DR: The aim of this study was to evaluate the potential role of Smad3 in the pathogenesis of colonic fibrosis induced by trinitrobenzene sulfonic acid (TNBS) in Smad 3 null mice.
Journal Article
Heterozygous Mice for the Transforming Growth Factor-β Type II Receptor Gene Have Increased Susceptibility to Hepatocellular Carcinogenesis
Young Hyuck Im,Heung Tae Kim,Isaac Yi Kim,Valentina M. Factor,Ki Baik Hahm,Mario A. Anzano,Ja-June Jang,Kathleen C. Flanders,Diana C. Haines,Snorri S. Thorgeirsson,Andrew Sizeland,Seong-Jin Kim +11 more
TL;DR: It is indicated that the reduced expression of TbetaR-II in mice increases susceptibility to tumorigenesis in the liver and the treatment of these mice with the chemical carcinogen, diethylnitrosamine, results in a significantly enhanced tumorigenisation in the Liver.