K
Kathleen C. Flanders
Researcher at National Institutes of Health
Publications - 150
Citations - 19846
Kathleen C. Flanders is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 68, co-authored 150 publications receiving 19278 citations. Previous affiliations of Kathleen C. Flanders include Gyeongsang National University & New York State Department of Health.
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Journal ArticleDOI
Smad3 as a mediator of the fibrotic response
TL;DR: It is shown that inhibition of Smad3 by overexpression of the inhibitory Smad7 protein or by treatment with the small molecule, halofuginone, dramatically reduces responses in animal models of kidney, lung, liver and radiation‐induced fibrosis.
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Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.
Pamela Gehron Robey,Marian F. Young,Kathleen C. Flanders,Nanette S. Roche,Paturu Kondaiah,A. H. Reddi,John D. Termine,Michael B. Sporn,Anita B. Roberts +8 more
TL;DR: It is concluded that bone-forming cells are a source for the TGF-beta that is found in bone, and that these cells may be modulated by this factor in an autocrine fashion.
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Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture
TL;DR: It is demonstrated that the expression of each of the two forms of TGF‐β is independently regulated, and sensitive and specific immunological assays for TGF •β1 and •β2 in complex biological fluids are described.
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Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice.
Nancy L. Thompson,Kathleen C. Flanders,J M Smith,L R Ellingsworth,Anita B. Roberts,Michael B. Sporn +5 more
TL;DR: The present data lend further support to the concept that TGF-beta has an important role in controlling interactions between epithelia and surrounding mesenchyme.
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Localization and actions of transforming growth factor-beta s in the embryonic nervous system.
Kathleen C. Flanders,G. Ludecke,S. Engels,David S. Cissel,Anita B. Roberts,Paturu Kondaiah,Robert Lafyatis,Michael B. Sporn,K. Unsicker +8 more
TL;DR: The data suggest that TGF-beta s 2 and 3 may play a role in regulation of neuronal migration and differentiation, as well as in glial cell proliferation and differentiation.