K
Kathleen C. Flanders
Researcher at National Institutes of Health
Publications - 150
Citations - 19846
Kathleen C. Flanders is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 68, co-authored 150 publications receiving 19278 citations. Previous affiliations of Kathleen C. Flanders include Gyeongsang National University & New York State Department of Health.
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Journal ArticleDOI
Cell Type-Specific Expression of Transforming Growth Factor-β 1 in the Mouse Uterus during the Periimplantation Period
TL;DR: The colocalization of intracellular staining by anti-LC with in situ hybridization of TGF beta 1 mRNA in the luminal and glandular epithelia on days 1-4 of pregnancy indicates that the epithelial cells are the primary sites of T GF beta 1 synthesis during the preimplantation period.
Journal Article
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.
Melinda S. Yates,Masafumi Tauchi,Fumiki Katsuoka,Kathleen C. Flanders,Karen T. Liby,Tadashi Honda,Gordon W. Gribble,Delinda A. Johnson,Jeffrey A. Johnson,Neal C. Burton,Tomás R. Guilarte,Masayuki Yamamoto,Michael B. Sporn,Thomas W. Kensler +13 more
TL;DR: Sporn et al. as discussed by the authors characterized the pharmacodynamic activity of imidazolide triterpenoid derivative, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im or TP235), by measuring increases in Nqo1 transcript levels as a marker of cytoprotective gene induction.
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Smad3: A Key Player in Pathogenetic Mechanisms Dependent on TGF‐β
TL;DR: The dramatic results of the absence of Smad3 on parameters of healing of cutaneous wounds, such as reepithelialization and influx of inflammatory cells, as well as on fibrosis as modeled by radiation fibrosis of skin in mice, suggest that signaling flux through Smad 3 is critical for chemotactic activity of TGF‐β.
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Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis
TL;DR: The results indicate colocalization of TGF-beta 1 expression and that of matrix proteins in the developing lung when branching morphogenesis (cleft formation) and tissue stabilization occur, and suggests a direct participation of the growth factor in the development of the basic architecture of the lung.
Journal ArticleDOI
Transforming Growth Factor Beta-1 in Acute Myocardial Infarction in Rats
Nancy L. Thompson,Fernando Bazoberry,Edith Speir,Ward Casscells,Victor J. Ferrans,Kathleen C. Flanders,Patljru Kondaiah,Andrew G. Geiser,Michael B. Sporn +8 more
TL;DR: A significant role for TGF-beta in the response of the heart to injury is indicated, as shown by the results of immunohistochemical staining and Northern blot analysis of mRNA.