S
Seong-Jin Kim
Researcher at Seoul National University
Publications - 267
Citations - 6260
Seong-Jin Kim is an academic researcher from Seoul National University. The author has contributed to research in topics: Cancer & Transforming growth factor. The author has an hindex of 40, co-authored 234 publications receiving 5327 citations. Previous affiliations of Seong-Jin Kim include Korea Institute of Science and Technology & Virginia Tech.
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Journal Article
Nodularin, a Potent Inhibitor of Protein Phosphatases 1 and 2A, Is a New Environmental Carcinogen in Male F344 Rat Liver
Tetsuya Ohta,Eisaburo Sueoka,Naoyuki Iida,Atsumasa Komori,Masami Suganuma,Rie Nishiwaki,Masae Tatematsu,Seong-Jin Kim,Wayne W. Carmichael,Hirota Fujiki +9 more
TL;DR: Nodularin itself is a new liver carcinogen and microcystin-LR is a tumor promoter rather than a carcinogen, and the need for prevention measures against cyanobacterial toxins is indicated.
Journal ArticleDOI
The tiger genome and comparative analysis with lion and snow leopard genomes
Yun Sung Cho,Li Hu,Haolong Hou,Hang Lee,Jiaohui Xu,Soowhan Kwon,Sukhun Oh,Hak-Min Kim,Sungwoong Jho,Sangsoo Kim,Young Ah Shin,Byung Chul Kim,Hyunmin Kim,Chang Uk Kim,Shu-Jin Luo,Warren E. Johnson,Klaus-Peter Koepfli,Anne Schmidt-Küntzel,Jason A. Turner,Laurie Marker,Cindy Kim Harper,Susan M. Miller,Susan M. Miller,Wilhelm Jacobs,Laura D. Bertola,Tae Hyung Kim,Sunghoon Lee,Qian Zhou,Hyun Ju Jung,Xiao Xu,Priyvrat Gadhvi,Pengwei Xu,Yingqi Xiong,Yadan Luo,Shengkai Pan,Caiyun Gou,Xiuhui Chu,Jilin Zhang,Sanyang Liu,Jing He,Ying Chen,Linfeng Yang,Yulan Yang,Jiaju He,Sha Liu,Junyi Wang,Chulhong Kim,Hwanjong Kwak,Jong-Soo Kim,Seungwoo Hwang,Junsu Ko,Chang Bae Kim,Sangtae Kim,Damdin Bayarlkhagva,Woon Kee Paek,Seong-Jin Kim,Stephen J. O'Brien,Stephen J. O'Brien,Jun Wang,Jun Wang,Jong Bhak +60 more
TL;DR: Comparison genetic analyses of the genomes of a white Bengal tiger, African lion, white African lion and snow leopard find genetic signatures that may reflect molecular adaptations consistent with the big cats’ hypercarnivorous diet and muscle strength.
Journal ArticleDOI
A public resource facilitating clinical use of genomes
Madeleine Ball,Joseph V. Thakuria,Alexander Wait Zaranek,Tom Clegg,Abraham M. Rosenbaum,Xiaodi Wu,Misha Angrist,Jong Bhak,Jason Bobe,Matthew J. Callow,Carlos Cano,Michael F. Chou,Wendy K. Chung,Shawn M. Douglas,Preston W. Estep,Athurva Gore,Peter J. Hulick,Alberto Labarga,Je-Hyuk Lee,Jeantine E. Lunshof,Byung Chul Kim,Jong Il Kim,Zhe Li,Michael F. Murray,Geoffrey B. Nilsen,Brock A. Peters,Anugraha M. Raman,Hugh Y. Rienhoff,Kimberly Robasky,Matthew T. Wheeler,Ward Vandewege,Daniel B. Vorhaus,Joyce L. Yang,Luhan Yang,John Aach,Euan A. Ashley,Radoje Drmanac,Seong-Jin Kim,Jin Billy Li,Leonid Peshkin,Christine E. Seidman,Jeong-Sun Seo,Kun Zhang,Heidi L. Rehm,George M. Church +44 more
TL;DR: A peer production system for recording and organizing variant evaluations according to standard evidence guidelines is developed, creating a public forum for reaching consensus on interpretation of clinically relevant variants.
Journal Article
Regulation of transforming growth factor beta1 by nitric oxide.
Yoram Vodovotz,Louis Chesler,Hyonkyong Chong,Seong-Jin Kim,John T. Simpson,William DeGraff,George W. Cox,Anita B. Roberts,David A. Wink,Mary Helen Barcellos-Hoff +9 more
TL;DR: Results provide the first evidence that nitrosative stress influences the regulation of TGF-beta1 and raise the possibility that NO production may augment TGF -beta1 activity by modifying a naturally occurring neutralizing peptide.
Journal ArticleDOI
Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway.
Byung-Chul Kim,Hong Gyum Kim,Sin Ae Lee,Seunghwan Lim,Eun-Hee Park,Seong-Jin Kim,Chang Jin Lim +6 more
TL;DR: It is demonstrated that genipin induces apoptotic cell death in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells, detected by morphological cellular changes, caspase activation and release of cytochrome c.