K
Kathleen C. Flanders
Researcher at National Institutes of Health
Publications - 150
Citations - 19846
Kathleen C. Flanders is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 68, co-authored 150 publications receiving 19278 citations. Previous affiliations of Kathleen C. Flanders include Gyeongsang National University & New York State Department of Health.
Papers
More filters
Journal ArticleDOI
Effect of overexpression of pparγ on the healing process of corneal alkali burn in mice
Shizuya Saika,Osamu Yamanaka,Yuka Okada,Takeshi Miyamoto,Ai Kitano,Kathleen C. Flanders,Yoshitaka Ohnishi,Yuji Nakajima,Winston W.-Y. Kao,Kazuo Ikeda +9 more
TL;DR: It is shown that adenoviral gene introduction of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibits activation of ocular fibroblasts and macrophages in vitro and also induced anti-inflammatory and anti-fibrogenic responses in an alkali-burned mouse cornea, suggesting that overexpression of PPARGamma may represent an effective new strategy for treatment of oocular surface burns.
Journal ArticleDOI
Transforming Growth Factor-βs and Mammary Gland Involution; Functional Roles and Implications for Cancer Progression
TL;DR: The putative role of TGF-β during involution is discussed, as well as its effects on the mammary microenvironment and possible implications for pregnancy-associated tumorigenesis.
Journal ArticleDOI
Epithelial-Mesenchymal Transition as a Therapeutic Target for Prevention of Ocular Tissue Fibrosis
Shizuya Saika,Osamu Yamanaka,Kathleen C. Flanders,Yuka Okada,Takeshi Miyamoto,Takayoshi Sumioka,Kumi Shirai,Ai Kitano,Ken-ichi Miyazaki,Sai-ichi Tanaka,Kazuo Ikeda +10 more
TL;DR: EMT in retinal pigment epithelium is involved in the development of another ocular fibrotic disease, proliferative vitreoretinopathy, a fibrosis in the retina, and EMT-related signal transduction cascades, i.
Journal ArticleDOI
Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis.
Henry W. Murray,Kathleen C. Flanders,Debra D. Donaldson,Joseph P. Sypek,Philip Gotwals,Jianguo Liu,Xiaojing Ma +6 more
TL;DR: IL-10 appears to be the appropriate target for therapeutic inhibition in visceral L. donovani infection, as it enhances Th1-cell-associated responses, promoting gamma interferon secretion, granuloma assembly, macrophage activation with substantial liver parasite killing, and synergy with pentavalent antimony chemotherapy.
Journal ArticleDOI
Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure
Praveen R. Arany,Kathleen C. Flanders,Tetsu Kobayashi,Catherine K. Kuo,Christina H. Stuelten,Kartiki V. Desai,Rocky S. Tuan,Stephen I. Rennard,Anita B. Roberts +8 more
TL;DR: It is reported that excisional ear wounds in mice lacking Smad3 enlarge compared with wild-type controls resulting from changes in extracellular matrix molecules, which alter the mechanotransduction properties of these wounds.