K
Kathleen C. Flanders
Researcher at National Institutes of Health
Publications - 150
Citations - 19846
Kathleen C. Flanders is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 68, co-authored 150 publications receiving 19278 citations. Previous affiliations of Kathleen C. Flanders include Gyeongsang National University & New York State Department of Health.
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Journal ArticleDOI
Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.
TL;DR: The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.
Journal Article
A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity
Nanjoo Suh,Yongping Wang,Tadashi Honda,Gordon W. Gribble,Ethan Dmitrovsky,William F. Hickey,Robert A. Maue,Andrew E. Place,Donna M. Porter,Michael J. Spinella,Charlotte R. Williams,Gengfei Wu,Andrew J. Dannenberg,Kathleen C. Flanders,John J. Letterio,David J. Mangelsdorf,Carl Nathan,Lananh Nguyen,Weston Porter,Renee F. Ren,Anita B. Roberts,Nanette S. Roche,Kotha Subbaramaiah,Michael B. Sporn +23 more
TL;DR: The results suggest that CDDO needs further study in vivo, for either chemoprevention or chemotherapy of malignancy as well as for neuroprotection.
Journal ArticleDOI
Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system
TL;DR: Transforming growth factor-beta 2- and 3-immunoreactive neurons were localized in brain regions that have been shown to contain neurons synthesizing and/or storing basic fibroblast growth factor suggesting possible opposing or synergistic effects of these peptide growth factors.
Journal ArticleDOI
Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease.
Yoram Vodovotz,M S Lucia,Kathleen C. Flanders,Louis Chesler,Qiao-wen Xie,Thomas W. Smith,J Weidner,R Mumford,R Webber,Carl Nathan,Anita B. Roberts,C F Lippa,Michael B. Sporn +12 more
TL;DR: Human neurons can express NOS2 in vivo, and the high-output pathway of NO production may contribute to pathogenesis in AD.
Journal ArticleDOI
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
Melinda S. Yates,Masafumi Tauchi,Fumiki Katsuoka,Kathleen C. Flanders,Karen T. Liby,Tadashi Honda,Gordon W. Gribble,Delinda A. Johnson,Jeffrey A. Johnson,Neal C. Burton,Tomás R. Guilarte,Masayuki Yamamoto,Michael B. Sporn,Thomas W. Kensler +13 more
TL;DR: The pharmacodynamic activity of CDDO-Im is characterized in two distinct lines of ARE reporter mice and by measuring increases in Nqo1 transcript levels as a marker of cytoprotective gene induction, highlighting the chemopreventive promise of several synthetic triterpenoids in multiple target organs.