K
Kathleen M. Loomes
Researcher at Children's Hospital of Philadelphia
Publications - 144
Citations - 4009
Kathleen M. Loomes is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Alagille syndrome & Cholestasis. The author has an hindex of 32, co-authored 122 publications receiving 2996 citations. Previous affiliations of Kathleen M. Loomes include University of Pennsylvania & Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania.
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Journal ArticleDOI
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
Frances A. High,Min Min Lu,Warren S. Pear,Kathleen M. Loomes,Kathleen M. Loomes,Klaus H. Kaestner,Jonathan A. Epstein +6 more
TL;DR: It is shown that endothelial-specific deletion of Jag1 results in embryonic lethality and cardiovascular defects, recapitulating the Jag1 null phenotype, implying that the primary role of endothelial Jag1 is to potentiate the development of neighboring vascular smooth muscle.
Journal ArticleDOI
NOTCH2 mutations in Alagille syndrome
Binita M. Kamath,Robert C. Bauer,Kathleen M. Loomes,Grace Chao,Jennifer Gerfen,Anne L. Hutchinson,Winita Hardikar,Gideon M. Hirschfield,Paloma Jara,Ian D. Krantz,Pablo Lapunzina,Laura D Leonard,Simon C. Ling,Vicky L. Ng,Phuc Le Hoang,David A. Piccoli,Nancy B. Spinner +16 more
TL;DR: The importance of NOTCH2 as a second disease gene in ALGS is confirmed and the repertoire of the Notch2 related disease phenotype is expanded.
Journal ArticleDOI
Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development.
Frances A. High,Rajan Jain,Jason Z. Stoller,Nicole Antonucci,Min Min Lu,Kathleen M. Loomes,Klaus H. Kaestner,Warren S. Pear,Jonathan A. Epstein +8 more
TL;DR: Exogenous Fgf8 was sufficient to rescue the defect in endothelial-mesenchymal transition in explant assays of endocardial cushions following Notch inhibition within second heart field derivatives and suggests that perturbed Notch-Jagged signaling within secondHeart field progenitors accounts for some forms of congenital and adult cardiac disease.
Journal ArticleDOI
Use of Corticosteroids After Hepatoportoenterostomy for Bile Drainage in Infants With Biliary Atresia: The START Randomized Clinical Trial
Jorge A. Bezerra,Cathie Spino,John C. Magee,Benjamin L. Shneider,Philip J. Rosenthal,Kasper S. Wang,Jessi Erlichman,Barbara Haber,Barbara Haber,Paula M. Hertel,Saul J. Karpen,Nanda Kerkar,Nanda Kerkar,Kathleen M. Loomes,Jean P. Molleston,Karen F. Murray,Rene Romero,Kathleen B. Schwarz,Ross W. Shepherd,Frederick J. Suchy,Yumirle P. Turmelle,Peter F. Whitington,Jeffrey S. Moore,Averell H. Sherker,Patricia R. Robuck,Ronald J. Sokol +25 more
TL;DR: Among infants with biliary atresia who have undergone hepatoportoenterostomy, high-dose steroid therapy following surgery did not result in statistically significant treatment differences in bile drainage at 6 months, although a small clinical benefit could not be excluded.
Journal ArticleDOI
Characterization of Notch receptor expression in the developing mammalian heart and liver
Kathleen M. Loomes,Darren B. Taichman,Curtis L. Glover,Patrick T. Williams,Jonathan E. Markowitz,David A. Piccoli,H. Scott Baldwin,Rebecca J. Oakey +7 more
TL;DR: The temporal and spatial expression patterns of the Notch receptor genes in the developing mammalian heart and liver are defined in order to identify potential ligand/receptor interactions during embryogenesis.