Min Min Lu

TL;DR: Co-culture studies with neonatal myocytes indicate that isl1+ cells represent authentic, endogenous cardiac progenitors (cardioblasts) that display highly efficient conversion to a mature cardiac phenotype with stable expression of myocytic markers in the absence of cell fusion, intact Ca2+-cycling, and the generation of action potentials.

TL;DR: It is shown that ataxin 2 (ATXN2), a polyglutamine (polyQ) protein mutated in spinocerebellar ataxia type 2, is a potent modifier of TDP-43 toxicity in animal and cellular models.

TL;DR: A major role is suggested for this gene in the molecular etiology of VCFS/DGS using a cre-loxP strategy to generate mice that are hemizygous for a 1.5-3.0 Mb deletion corresponding to that on 22q11.

TL;DR: It is demonstrated that Hopx, an atypical homeobox protein, is a specific marker of +4 cells, which demonstrates a bidirectional lineage relationship between active and quiescent stem cells in their niches.

TL;DR: A model in which GATA6 lies upstream of HNF4 in a transcriptional cascade that regulates differentiation of the visceral endoderm is suggested and it is demonstrated that GATA 6 is required for establishment of the endODermally derived bronchial epithelium.