Kathleen M. Stewart

TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.

TL;DR: In this paper , the authors identify a distinct progenitor in a region of the human lung that is not found in mouse that has a critical role in maintaining the gas-exchange compartment and is altered in chronic lung disease.

TL;DR: RNA interference is utilized to reduce the amounts of BRM or BRG1 protein in the nonmalignant mammary epithelial cell line, MCF‐10A, and this results in an inhibition of cell proliferation in monolayer cultures, suggesting that SWI/SNF ATPases promote cell cycle progression in non malignant mammaries epithelial cells.

TL;DR: The findings identify a novel mechanism whereby oncogenic signaling promotes malignant transformation by regulating transcription of a key chromatin remodeling molecule that regulates integrin-dependent stromal–epithelial interactions.

TL;DR: A novel computational pipeline to utilize the LungMAP CellCards as a dictionary to consolidate single-cell transcriptomic datasets of 104 human lungs and 17 mouse lung samples is developed and the utility of the CellRefs for automated cell type annotation analysis of both normal and disease lungs is demonstrated.