J
James F. Curtin
Researcher at University College Dublin
Publications - 105
Citations - 5749
James F. Curtin is an academic researcher from University College Dublin. The author has contributed to research in topics: Chemistry & Glioma. The author has an hindex of 34, co-authored 88 publications receiving 4935 citations. Previous affiliations of James F. Curtin include Cedars-Sinai Medical Center & University of California, Los Angeles.
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Journal ArticleDOI
Isolation of cancer stem cells from adult glioblastoma multiforme
Xiangpeng Yuan,James F. Curtin,Yizhi Xiong,Gentao Liu,Sebastian Waschsmann-Hogiu,Daniel L. Farkas,Keith L. Black,John S. Yu +7 more
TL;DR: The identification of tumor stem cells within adult GBM may represent a major step forward in understanding the origin and maintenance of GBM and lead to the identification and testing of new therapeutic targets.
Journal ArticleDOI
Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications
TL;DR: It was found that inclusion of alloying elements such as Al, Mn, Ca, Zn and rare earth elements provides improved corrosion resistance to Mg alloys and surface modification is a promising approach to improve the performance of Mg-based biomaterials for orthopaedic applications.
Journal ArticleDOI
Regulation and measurement of oxidative stress in apoptosis.
TL;DR: The major sources of ROS and RNI in a cell, the control of cell death by these species and the role of antioxidants as regulators of oxidative stress and apoptosis are described.
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HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
James F. Curtin,James F. Curtin,Naiyou Liu,Naiyou Liu,Marianela Candolfi,Marianela Candolfi,Weidong Xiong,Weidong Xiong,Hikmat Assi,Hikmat Assi,Kader Yagiz,Kader Yagiz,Matthew R. Edwards,Kathrin S. Michelsen,Kurt M. Kroeger,Kurt M. Kroeger,Chunyan Liu,Chunyan Liu,A.K.M. Ghulam Muhammad,A.K.M. Ghulam Muhammad,Mary C. Clark,Mary C. Clark,Moshe Arditi,Begonya Comin-Anduix,Antoni Ribas,Pedro R. Lowenstein,Maria G. Castro +26 more
TL;DR: Evidence is provided for the molecular and cellular mechanisms that support the rationale for the clinical implementation of antibrain cancer immunotherapies in combination with tumor killing approaches in order to elicit effective antitumor immune responses, and thus, will impact clinical neuro-oncology practice.
Journal ArticleDOI
Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression
Marianela Candolfi,Marianela Candolfi,James F. Curtin,James F. Curtin,W. Stephen Nichols,Akm Ghulam Muhammad,Gwendalyn D. King,Gwendalyn D. King,G. Elizabeth Pluhar,Elizabeth A. McNiel,John R. Ohlfest,Andrew Freese,Peter F Moore,Jonathan Lerner,Jonathan Lerner,Pedro R. Lowenstein,Pedro R. Lowenstein,Maria G. Castro,Maria G. Castro +18 more
TL;DR: The data indicate that murine models of GBM appear to recapitulate several of the human GBM histopathological features and, considering their reproducibility and availability, they constitute a valuable in vivo system for preclinical studies.