K
Kathryn M. Lemberg
Researcher at Columbia University
Publications - 6
Citations - 7267
Kathryn M. Lemberg is an academic researcher from Columbia University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications receiving 3384 citations. Previous affiliations of Kathryn M. Lemberg include Howard Hughes Medical Institute.
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Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
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Functional model of metabolite gating by human voltage-dependent anion channel 2.
Andras J. Bauer,Simone Gieschler,Kathryn M. Lemberg,Ann E. McDermott,Brent R. Stockwell,Brent R. Stockwell +5 more
TL;DR: This work presents an in vitro system that provides a platform for both functional and structural investigation of hVDAC2 and its small molecule modulator, erastin, and found that Erastin increases permeability of VDAC2 liposomes to NADH in a manner that requires the amino-terminal region of V DAC2.
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Clinical development of metabolic inhibitors for oncology
TL;DR: The goal of this Review is to provide an overview of the landscape of metabolic inhibitors in clinical development for oncology, and evaluate the preclinical studies demonstrating antitumor and TME effects and review ongoing clinical trials.
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Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
Rana Rais,Kathryn M. Lemberg,Lukáš Tenora,Matthew L. Arwood,Arindom Pal,Jesse Alt,Ying Wu,Jenny Lam,Joanna Marie H. Aguilar,Xiang Zhao,Diane E. Peters,Carolyn Tallon,Rajeev Kumar Pandey,Ajit G. Thomas,Ranjeet Prasad Dash,Tanguy Y. Seiwert,Pavel Majer,Robert Leone,Jonathan D. Powell,Barbara S. Slusher +19 more
TL;DR: In this article, the authors designed DON peptide prodrugs and found DRP-104 that was preferentially bioactivated to DON in tumor while bioinactivated to an inert metabolite in GI tissues.
Journal ArticleDOI
Trainee-led Engagement of the Care Team Improves Application of an Institutional Blood Culture Clinical Decision Algorithm to Pediatric Oncology Inpatients: A Single-institution Quality Improvement Project
Kathryn M. Lemberg,Danielle W Koontz,David J. Young,P. DiDomizio,Anne F King,Allen R. Chen,Christopher Gamper,Elizabeth Colantuoni,Aaron M. Milstone,Stacy L. Cooper +9 more
TL;DR: Implementation of a clinical decision algorithm reduced the rate of cultures drawn on pediatric oncology inpatients and fellow-led education of the care team decreased the proportion of nonadherent culture episodes and provided active engagement in QI.