K
Kathryn Wolhuter
Researcher at Victor Chang Cardiac Research Institute
Publications - 7
Citations - 261
Kathryn Wolhuter is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: cGMP-dependent protein kinase & Resveratrol. The author has an hindex of 4, co-authored 7 publications receiving 187 citations. Previous affiliations of Kathryn Wolhuter include King's College London & St Thomas' Hospital.
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Journal ArticleDOI
Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation.
Kathryn Wolhuter,Harry J. Whitwell,Christopher H. Switzer,Joseph R. Burgoyne,John F. Timms,Philip Eaton +5 more
TL;DR: The current widely held perception that stable S-nitrosation directly regulates the function of many proteins is significantly incorrect, and it is proposed that S-Nitrosation primarily serves as a transient intermediate leading to disulfide formation.
Journal ArticleDOI
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation
Christopher P. Stanley,Ghassan J. Maghzal,Ghassan J. Maghzal,Anita Ayer,Anita Ayer,Jihan Talib,Jihan Talib,Andrew M. Giltrap,Sudhir Shengule,Kathryn Wolhuter,Yutang Wang,Yutang Wang,Preet S. Chadha,Cacang Suarna,Oleksandra Prysyazhna,Oleksandra Prysyazhna,Jenna Scotcher,Jenna Scotcher,Louise L. Dunn,Louise L. Dunn,Fernanda M. Prado,Nghi H. Nguyen,Jephthah O. Odiba,Jonathan B. Baell,Jonathan B. Baell,Johannes-Peter Stasch,Yorihiro Yamamoto,Paolo Di Mascio,Philip Eaton,Philip Eaton,Richard J. Payne,Roland Stocker,Roland Stocker +32 more
TL;DR: Singlet molecular oxygen, produced by indoleamine 2,3-dioxygenase 1 activity, gives rise to a signalling molecule that regulates arterial relaxation under inflammatory conditions, demonstrating a pathophysiological role for 1O2 in mammals through formation of an amino acid-derived hydroperoxide that regulates vascular tone and blood pressure underinflammatory conditions.
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Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase.
Oleksandra Prysyazhna,Kathryn Wolhuter,Christopher H. Switzer,Celio X.C. Santos,Xiaoping Yang,Steven Lynham,Ajay M. Shah,Philip Eaton,Joseph R. Burgoyne +8 more
TL;DR: This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals.
Journal ArticleDOI
How widespread is stable protein S-nitrosylation as an end-effector of protein regulation?
Kathryn Wolhuter,Philip Eaton +1 more
TL;DR: This review presents evidence and explains the reasoning for arriving at this conclusion that may be controversial to some researchers in the field, that protein S‐nitrosation mainly serves as a redox‐state intermediate leading to disulfide.
Journal ArticleDOI
Air pollution and cardiovascular disease: Can the Australian bushfires and global COVID-19 pandemic of 2020 convince us to change our ways?
TL;DR: In this article, the authors provide an overview of the cardiovascular effects of air pollution and use two major events of 2020-the Australian bushfires and COVID-19 pandemic lockdown-to illustrate the relationship between exposure to airborne pollutants and the onset of cardiovascular disease (CVD).