K
Katrin Henke
Researcher at Boston Children's Hospital
Publications - 28
Citations - 858
Katrin Henke is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Zebrafish & Biology. The author has an hindex of 13, co-authored 24 publications receiving 638 citations. Previous affiliations of Katrin Henke include Max Planck Society & Harvard University.
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Journal ArticleDOI
Microglia in the developing brain: from immunity to behaviour.
TL;DR: Novel roles are emerging that strikingly link microglia with higher order brain functions and show that these cells can ultimately influence behaviour and open unprecedented perspectives in the prevention and treatment of neuropsychiatric diseases.
Journal ArticleDOI
Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number
Wen Fan Hu,Oz Pomp,Tawfeg Ben-Omran,Andrew Kodani,Katrin Henke,Katrin Henke,Ganeshwaran H. Mochida,Timothy W. Yu,Timothy W. Yu,Mollie B. Woodworth,Carine Bonnard,Grace Selva Raj,Thong Teck Tan,Hanan Hamamy,Amira Masri,Mohammad Shboul,Muna Al Saffar,Muna Al Saffar,Jennifer N. Partlow,Jennifer N. Partlow,Mohammed S. Al-Dosari,Anas M. Alazami,Mohammed Al-Owain,Fowzan S. Alkuraya,Jeremy F. Reiter,Matthew P. Harris,Matthew P. Harris,Bruno Reversade,Bruno Reversade,Christopher A. Walsh +29 more
TL;DR: Surprisingly, Katnb1 null mutant mouse embryos display hallmarks of aberrant Sonic hedgehog signaling, including holoprosencephaly, and KATNB1 null fibroblasts also demonstrate a remarkable excess of centrioles, with supernumerary cilia but deficient Hedgehog signaling.
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Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies
Charlotte Gistelinck,Charlotte Gistelinck,Ronald Y. Kwon,Fransiska Malfait,Sofie Symoens,Matthew P. Harris,Matthew P. Harris,Katrin Henke,Katrin Henke,Michael Brent Hawkins,Michael Brent Hawkins,Shannon Fisher,Patrick Sips,Brecht Guillemyn,Jan Willem Beck,Petra Vermassen,Hanna De Saffel,Paul Witten,MaryAnn Weis,Anne De Paepe,David R. Eyre,Andy Willaert,Paul Coucke +22 more
TL;DR: The future potential of zebrafish as a tool to further dissect the molecular basis of phenotypic variability in human type I collagenopathies is illustrated to improve diagnostic strategies as well as promote the discovery of new targetable pathways for pharmacological intervention of these disorders.
Journal ArticleDOI
Efficient Mapping and Cloning of Mutations in Zebrafish by Low-Coverage Whole-Genome Sequencing
Margot E. Bowen,Katrin Henke,Katrin Henke,Kellee R. Siegfried,Matthew L. Warman,Matthew L. Warman,Matthew P. Harris,Matthew P. Harris +7 more
TL;DR: A method for efficiently mapping and detecting mutations in zebrafish using these new parallel sequencing technologies and evidence that one of the identified mutations, a nonsense mutation in bmp1a, underlies the welded mutant phenotype is provided.
Journal ArticleDOI
Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein
Andrew Dauber,Stephen H. LaFranchi,Zoltan Maliga,Julian C. Lui,Jennifer E. Moon,Cailin McDeed,Katrin Henke,Jonathan Zonana,Garrett A. Kingman,Garrett A. Kingman,Tune H. Pers,Jeffrey Baron,Ron G. Rosenfeld,Joel N. Hirschhorn,Matthew P. Harris,Vivian Hwa +15 more
TL;DR: It is shown, for the first time, that reduction of ninein function in the developing zebrafish leads to specific deficiencies of brain and skull development, offering a developmental basis for the myriad phenotypes in patients.