Petra Vermassen

TL;DR: It is reported that expression of wild-type but not of mutated SIP1 downregulates mammalian E-cadherin transcription via binding to both conserved E2 boxes of the minimal E- cadheringin promoter.

TL;DR: It is shown that expression of SIP1 in human epithelial cells results in a clear morphological change from an epithelial to a mesenchymal phenotype, and repression occurs by a general mechanism mediated by Smad Interacting Protein 1 (SIP1)-binding sites.

TL;DR: The future potential of zebrafish as a tool to further dissect the molecular basis of phenotypic variability in human type I collagenopathies is illustrated to improve diagnostic strategies as well as promote the discovery of new targetable pathways for pharmacological intervention of these disorders.

TL;DR: The present results suggest that metastasin-induced invasiveness of several malignant tumor cells is at least partially caused by down-regulation of E-cadherin.

TL;DR: In vivo expression of Snail results in de novo epithelial carcinogenesis by allowing enhanced survival, expansion of the cancer stem cell pool with accumulated DNA damage, a block in terminal differentiation and increased proliferation rates of tumour-initiating cells.