Katrin Strohmer

TL;DR: “multiplexed proteome dynamics profiling” (mPDP), a mass-spectrometry-based approach combining dynamic-SILAC labeling with isobaric mass tagging for multiplexed analysis of protein degradation and synthesis, highlights the potential of mPDP to identify dynamically controlled degradation mechanisms in cellular systems.

TL;DR: Tissue thermal proteome profiling (tissue-TPP), which measures binding of small-molecule drugs to proteins in tissue samples from drug-treated animals by detecting changes in protein thermal stability using quantitative mass spectrometry, is introduced.

TL;DR: GSK8612 is a TBK1 small molecule inhibitor displaying an excellent selectivity profile and therefore represents an ideal probe to further dissect the biology ofTBK1 in models of immunity, neuroinflammation, obesity, or cancer.

TL;DR: It is demonstrated that GSK5628 inhibits IDO1 by competing with heme for binding to a heme‐free conformation of the enzyme (apo‐IDO1), whereas epacadostat coordinates its binding with the iron atom of the IDO 1 heme cofactor.

TL;DR: It is demonstrated that GSK5628 inhibits IDO1 by competing with heme for binding to a heme-free conformation of the enzyme (apo-IDO1) while epacadostat coordinates its binding with the iron atom of the IDO2 heme cofactor.