Katryn J. Stacey

TL;DR: This work identifies the HIN-200 family member and candidate lupus susceptibility factor, p202, as a dsDNA binding protein that bound stably and rapidly to transfected DNA and indicates that Hin-200 proteins can act as pattern recognition receptors mediating responses to cytoplasmic ds DNA.

TL;DR: Results suggest that DNA is taken up by macrophages and characteristic bacterial DNA sequences, which include an unmethylated CpG sequence, activate a signaling cascade leading to activation of NF-kappa B and inflammatory gene induction.

TL;DR: It is shown that AIM2 and NLRP3 inflammasomes activate caspase-8 and -1, leading to both apoptotic and pyroptotic cell death, with little or no requirement for casp enzyme-9.

TL;DR: It is shown that the secreted form of the dengue virus nonstructural protein 1 (NS1) is a pathogen-associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via Toll-like receptor 4 (TLR4), resulting in release of inflammatory cytokines—an effect that was blocked by either a TLR4 antagonist or an anti-TLR 4 antibody.

TL;DR: It is reported that in the cell, the dominant species of active caspase-1 dimers elicited by inflammasomes are in fact full-length p46 and a transient species, p33/p10, which offers a molecular basis for the transient nature, and coordinated timing, ofinflammasome-dependent inflammatory responses.