Daniel Watterson

TL;DR: It is shown that the secreted form of the dengue virus nonstructural protein 1 (NS1) is a pathogen-associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via Toll-like receptor 4 (TLR4), resulting in release of inflammatory cytokines—an effect that was blocked by either a TLR4 antagonist or an anti-TLR 4 antibody.

TL;DR: This review highlights recent advances in elucidating the molecular mechanisms underpinning NS1 function and presents the current state of play and some future prospects for NS1 targeted antiviral strategies.

TL;DR: Two monoclonal antibodies which show co-localised staining with proteins involved in viral RNA replication in immunofluorescence assay (IFA), suggesting specific reactivity to viral dsRNA are developed and incorporated into a high-throughput, economical ELISA-based screening system for the detection and discovery of viruses from mosquito populations.

TL;DR: Two critical residues, K291 and K295, that are involved in GAG interactions are identified and demonstrated differential binding between mosquito and human cells and antiviral-activity assays.

TL;DR: In this paper, SARS-CoV-2 antigen-specific Fcγ receptor binding accurately distinguishes COVID-19 patients from healthy individuals, suggesting that SARS co-virus infection induces qualitative changes to antibody Fc, enhancing Fcαγ receptor engagement.