Katsuko Sudo

TL;DR: It is found that contact, delayed-type, and airway hypersensitivity responses, as well as T-dependent antibody production, were significantly reduced in the mutant mice, while IL-17 deficiency of donor T cells did not affect acute graft-versus-host reaction.

TL;DR: It is found that TPA (12-O-tetradecanoylphorbol-13-acetate)-induced ectodomain shedding of HB-EGF is markedly reduced in embryonic fibroblasts prepared from Meltrin α-deficient mice, and Heparin-binding epidermal growth factor-like growth factor is a candidate substrate of Meltrinα.

TL;DR: It is shown that the loss of a single non-reducing terminal carbohydrate residue attenuates brain higher functions in mice generated with a targeted deletion of the GlcAT-P gene.

TL;DR: Results suggest that caspase-8 is indispensable for embryonic development, and homozygous mutant neural and heart defects were rescued by ex vivo whole-embryo culture during E10.5–E11.5, suggesting that these defects are most likely secondary to a lack of physiological casp enzyme-8 activity.

TL;DR: The results suggest the necessity of proteolytic regulation of ErbB ligands by Meltrin h for proper heart development and suggest impaired growth and differentiation of the endocardial cushion.