K
Kay E. Davies
Researcher at University of Oxford
Publications - 580
Citations - 40236
Kay E. Davies is an academic researcher from University of Oxford. The author has contributed to research in topics: Duchenne muscular dystrophy & Dystrophin. The author has an hindex of 100, co-authored 573 publications receiving 38462 citations. Previous affiliations of Kay E. Davies include Case Western Reserve University & Technische Universität München.
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Journal ArticleDOI
The artificial zinc finger coding gene 'Jazz' binds the utrophin promoter and activates transcription.
Nicoletta Corbi,Valentina Libri,Maurizio Fanciulli,Jonathon M. Tinsley,Kay E. Davies,Claudio Passananti +5 more
TL;DR: It is demonstrated that Jazz protein binds specifically to the double-stranded DNA target, with a dissociation constant of about 32 nM, confirming the high affinity and specificity of Jazz protein for its DNA target.
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A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling
Gareth Jones,E Sang,C. A. Goddard,Russell J. Mortishire-Smith,Brian C. Sweatman,John N. Haselden,Kay E. Davies,Andrew A. Grace,Kieran Clarke,Julian L. Griffin +9 more
TL;DR: The metabolic profiles demonstrate that the strain background is an important component of the global metabolic phenotype of a mouse, providing insight into how a given gene deletion may result in very different responses in diverse populations.
Journal Article
Non-toxic ubiquitous overexpression of utrophin in the mdx mouse.
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Identification of the FRAXE fragile site in two families ascertained for X linked mental retardation.
G A Flynn,Mark C. Hirst,Samantha J. L. Knight,James N. Macpherson,John C. K. Barber,A. V. Flannery,Kay E. Davies,Veronica J. Buckle +7 more
TL;DR: Fluorescence in situ hybridisation with cosmid DNA from loci immediately flanking FRAXA and other distal loci has confirmed that cytogenetic fragility in these subjects is the result of expression of a new folate sensitive fragile X site, FRAxE.
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Rescue of skeletal muscle α-actin–null mice by cardiac (fetal) α-actin
Kristen J. Nowak,Gianina Ravenscroft,Connie Jackaman,Aleksandra Filipovska,Stefan M.K. Davies,Esther Lim,Sarah E. Squire,A Potter,Elizabeth Baker,Sophie Clément,Caroline Sewry,Victoria A. Fabian,Kelly M. Crawford,James L. Lessard,Lisa M. Griffiths,John Papadimitriou,Yun Shen,Grant Morahan,Anthony J. Bakker,Kay E. Davies,Nigel G. Laing +20 more
TL;DR: Findings indicate that ACTC is sufficiently similar to ACTA1 to produce adequate function in postnatal skeletal muscle, and raises the prospect thatACTC reactivation might provide a therapy forACTA1 diseases.