K
Kay E. Davies
Researcher at University of Oxford
Publications - 580
Citations - 40236
Kay E. Davies is an academic researcher from University of Oxford. The author has contributed to research in topics: Duchenne muscular dystrophy & Dystrophin. The author has an hindex of 100, co-authored 573 publications receiving 38462 citations. Previous affiliations of Kay E. Davies include Case Western Reserve University & Technische Universität München.
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Localisation of the endpoints of deletions in the 5′ region of the Duchenne gene using a sequence isolated by chromosome jumping
TL;DR: The single copy jump clone, HH1, was used to characterise deletions in patients previously shown to be deleted for DNA markers in the 5' end of the gene, and 12 out of 15 such patients have breakpoints which lie between HH1 and the genomic locus J-47.
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T.O.3 Tricyclo-DNA: A promising chemistry for the synthesis of antisense molecules for splice-switching approaches in DMD
Aurélie Goyenvalle,Arran Babbs,Aurélie Avril,G. Griffiths,Branislav Dugovic,Kay E. Davies,Christian J. Leumann,Luis Garcia +7 more
TL;DR: Findings indicate that Tc-DNA exhibit therapeutic, drug-like effects not only in relatively benign mdx mouse model but also in very severe DMD phenotype of dKO mouse, suggesting great potential for these compounds in the systemic treatment of DMD.
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Infantile autism, fragile (X) (q27.3) and RFLP analysis in an extended Swedish family.
TL;DR: In an extended family with eight individuals with infantile autism, in association with other developmental disorders and fragile (X) (q27.3), DNA techniques were used to investigate linkage between X chromosomal probes and the disorder.
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Rescue of a single yeast artificial chromosome from a cotransformation event utilizing segregation at meiosis
Andrea H. Németh,Neil Hunter,Michael P. Coleman,Rhona H. Borts,Edward J. Louis,Kay E. Davies +5 more
TL;DR: A simple method to rescue the required YAC that utilizes the segregation of chromosomes at meiosis is presented and it is concluded that this is a useful technique to rescue cotransformed YACs.