K
Kazimierz S. Kasprzak
Researcher at National Institutes of Health
Publications - 131
Citations - 6009
Kazimierz S. Kasprzak is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA damage & Nickel. The author has an hindex of 44, co-authored 131 publications receiving 5798 citations. Previous affiliations of Kazimierz S. Kasprzak include Polish Academy of Sciences & University of Wrocław.
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Journal ArticleDOI
Nickel carcinogenesis. Mutat Res
Journal ArticleDOI
Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress
Konstantin Salnikow,Steven P. Donald,Richard K. Bruick,Anatoly Zhitkovich,James M. Phang,Kazimierz S. Kasprzak +5 more
TL;DR: It is suggested that the observed depletion of ascorbate by nickel( II) or cobalt(II) favors iron oxidation and thus inactivation of the enzyme, which is essential for maintaining iron in prolyl hydroxylases in the active iron(II] state.
Journal ArticleDOI
Oxidative DNA and protein damage in metal-induced toxicity and carcinogenesis.
TL;DR: The presentation is focused on selected issues relative to genetic and epigenetic toxicity and illustrated with examples of metal-mediated oxidative damage to the principal components of chromatin, i.e., DNA, histones, and protamines.
Journal ArticleDOI
Induction of oxidative DNA damage by carcinogenic metals.
TL;DR: The binding sites for Ni(II) and Cu( II) in core histones and sperm protamines are proposed and evidence for the generation of promutagenic oxidative DNA damage by the bound metals is provided.