K
Kazufumi Obata
Researcher at Sapporo Medical University
Publications - 27
Citations - 576
Kazufumi Obata is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Tight junction & Cancer. The author has an hindex of 10, co-authored 24 publications receiving 446 citations.
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Journal ArticleDOI
Regulation of Tight Junctions in Upper Airway Epithelium
Takashi Kojima,Mitsuru Go,Kenichi Takano,Makoto Kurose,Tsuyoshi Ohkuni,Jun-ichi Koizumi,Ryuta Kamekura,Noriko Ogasawara,Tomoyuki Masaki,Jun Fuchimoto,Kazufumi Obata,Satoshi Hirakawa,Kazuaki Nomura,Takashi Keira,Ryou Miyata,Nobuhiro Fujii,Hiroyuki Tsutsumi,Tetsuo Himi,Norimasa Sawada +18 more
TL;DR: Recent progress in the understanding of the regulation of tight junctions in the upper airway epithelium under normal, allergic, and RSV-infected conditions is summarized.
Journal ArticleDOI
Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells.
Kazuaki Nomura,Kazufumi Obata,Takashi Keira,Ryo Miyata,Satoshi Hirakawa,Kenichi Takano,Takayuki Kohno,Norimasa Sawada,Tetsuo Himi,Takashi Kojima +9 more
TL;DR: The transient disruption of tight junctions by PE might occur repeatedly during chronic rhinosinusitis, and treatment with a PAR-2 agonist prevented the downregulation of the tight junction proteins after PE treatment in HNECs.
Journal ArticleDOI
Curcumin Prevents Replication of Respiratory Syncytial Virus and the Epithelial Responses to It in Human Nasal Epithelial Cells
Kazufumi Obata,Takashi Kojima,Tomoyuki Masaki,Tamaki Okabayashi,Shin-ichi Yokota,Satoshi Hirakawa,Kazuaki Nomura,Akira Takasawa,Masaki Murata,Satoshi Tanaka,Jun Fuchimoto,Nobuhiro Fujii,Hiroyuki Tsutsumi,Tetsuo Himi,Norimasa Sawada +14 more
TL;DR: Results suggest that curcumin can prevent the replication of RSV and the epithelial responses to it without cytotoxicity and may act as therapy for severe lower respiratory tract disease in infants and young children caused by RSV infection.
Journal ArticleDOI
A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells
Tomoyuki Masaki,Takashi Kojima,Tamaki Okabayashi,Noriko Ogasawara,Tsuyoshi Ohkuni,Kazufumi Obata,Akira Takasawa,Masaki Murata,Satoshi Tanaka,Satoshi Hirakawa,Jun Fuchimoto,Takafumi Ninomiya,Nobuhiro Fujii,Hiroyuki Tsutsumi,Tetsuo Himi,Norimasa Sawada +15 more
TL;DR: It is found that the replication of RSV and the epithelial cell responses including induction of tight junctions were regulated via a protein kinase C δ/hypoxia-inducible factor-1α/nuclear factor-κβ pathway, and the control of this pathway may be useful in therapy for RSV-induced respiratory pathogenesis.
Journal ArticleDOI
Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines
Kazuaki Nomura,Takashi Kojima,Jun Fuchimoto,Kazufumi Obata,Takashi Keira,Tetsuo Himi,Norimasa Sawada +6 more
TL;DR: This work investigated the signal transduction regulation of IL‐33 and TSLP induced by proinflammatory cytokines in nasal fibroblasts and found that these molecules regulated the regulation of epithelial cells and smooth muscle cells at nasal mucosal sites.