M
Makoto Kurose
Researcher at Sapporo Medical University
Publications - 40
Citations - 577
Makoto Kurose is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Tight junction & Barrier function. The author has an hindex of 10, co-authored 34 publications receiving 473 citations.
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Journal ArticleDOI
Regulation of Tight Junctions in Upper Airway Epithelium
Takashi Kojima,Mitsuru Go,Kenichi Takano,Makoto Kurose,Tsuyoshi Ohkuni,Jun-ichi Koizumi,Ryuta Kamekura,Noriko Ogasawara,Tomoyuki Masaki,Jun Fuchimoto,Kazufumi Obata,Satoshi Hirakawa,Kazuaki Nomura,Takashi Keira,Ryou Miyata,Nobuhiro Fujii,Hiroyuki Tsutsumi,Tetsuo Himi,Norimasa Sawada +18 more
TL;DR: Recent progress in the understanding of the regulation of tight junctions in the upper airway epithelium under normal, allergic, and RSV-infected conditions is summarized.
Journal ArticleDOI
Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells
Ryuta Kamekura,Takashi Kojima,Jun-ichi Koizumi,Noriko Ogasawara,Makoto Kurose,Mitsuru Go,Atsushi Harimaya,Masaki Murata,Satoshi Tanaka,Hideki Chiba,Tetsuo Himi,Norimasa Sawada +11 more
TL;DR: The nasal-epithelial-derived TSLP thus not only activates DCs but also preserves the epithelial barrier via the upregulation of tight-junction proteins, thereby regulating antigen sensitization during the early stage of allergic rhinitis.
Journal ArticleDOI
Protein Kinase C Enhances Tight Junction Barrier Function of Human Nasal Epithelial Cells in Primary Culture by Transcriptional Regulation
Jun-ichi Koizumi,Takashi Kojima,Noriko Ogasawara,Ryuta Kamekura,Makoto Kurose,Mitsuru Go,Atsushi Harimaya,Masaki Murata,Makoto Osanai,Hideki Chiba,Tetsuo Himi,Norimasa Sawada +11 more
TL;DR: It is suggested that TPA-induced PKC signaling enhances the barrier function of human nasal epithelial cells via transcriptional up-regulation of tight junction proteins, and the mechanisms may contribute to a drug delivery system.
Journal ArticleDOI
Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span
Makoto Kurose,Takashi Kojima,Jun-ichi Koizumi,Ryuta Kamekura,Takafumi Ninomiya,Masaki Murata,Shingo Ichimiya,Makoto Osanai,Hideki Chiba,Tetsuo Himi,Norimasa Sawada +10 more
TL;DR: The results indicate that hTERT-transfected human nasal epithelial cells with an extended lifespan can be used as an indispensable and stable model for studying the regulation of claudins inhuman nasal epithelium.
Journal ArticleDOI
Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids
Noriko Ogasawara,Takashi Kojima,Mitsuru Go,Kenichi Takano,Ryuta Kamekura,Tsuyoshi Ohkuni,Jun-ichi Koizumi,Tomoyuki Masaki,Jun Fuchimoto,Kazufumi Obata,Makoto Kurose,Tomoko Shintani,Norimasa Sawada,Tetsuo Himi +13 more
TL;DR: The lymphoepithelium of adenoids has well-developed tight junctions that play an important role in the barrier function, the same as nasal epithelium but not palatine tonsillar epithelia.